Critical care has excellent measures of severity of illness calibrated to mortality, but severity may be reflected in subsequent morbidity as well survival. A major challenge of critical care outcomes research and applicable to all medical outcomes and quality issues is the development of methods that predict the full range of outcomes from normal through the range of morbidities as well as death.
The AIM of this proposal is to develop and validate a predictor of 3 or more outcome states from pediatric intensive care: death, survival one or more states of reduced functional status, and survival with normal or unchanged functional status. Preliminary Studies demonstrate a) the feasibility of the statistical approach and b) the applicability and utility of a new functional status assessment method (Functional Status Score, FSS) developed by the CPCCRN and by this PI for the purpose of this proposal. METHODS: Consecutive patients without exclusion from the participating PICUS will be utilized. Core data will consist of physiological data, diagnoses, age and other demographic information, FSS (pre-admission, PICU discharge, hospital discharge), survival/death (PICU and hospital), therapies affecting functional status, imaging, Outcome prediction for multiple functional states with normal function and death being the extreme will include both """"""""simple"""""""" linear models with the FSS contributing the gradations of outcome, and polychotomous logistic regression analysis for models of 3 or more discrete outcome states. Statistical models will use up to 12 predictor variables including PRISM III score without neurological variables, neurological variables only, pre- ICU care area, operative status, diagnoses (up to 6), age, baseline FSS. Statistical methods will include """"""""simple"""""""" linear regression conceptualizing outcome on a scale of normal to death with worsening functional states in between and polychotomous logistic regression utilizing the FSS to define 2 of more outcome states in addition to death. Sample size estimates based on a 4% mortality rate and a 4% new severe functional status are 5067 but will be re-estimated when units are selected.

Public Health Relevance

Shifting the paradigm of severity assessment by advancing its conceptual and statistical foundations will stimulate change. Important advances could occur in quality research and methods, long-term outcome forecasting including pediatric disability at PICU discharge, and decision making by including severely decreased functional status probabilities as well as mortality probabilities based on admission severity.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD063114-04
Application #
8402389
Study Section
Special Emphasis Panel (ZHD1-DSR-A (25))
Program Officer
Maholmes, Valerie
Project Start
2009-12-24
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
4
Fiscal Year
2013
Total Cost
$259,482
Indirect Cost
$92,074
Name
Phoenix Children's Hospital
Department
Type
DUNS #
110443595
City
Phoenix
State
AZ
Country
United States
Zip Code
85016
Pollack, Murray M; Holubkov, Richard; Berg, Robert A et al. (2018) Predicting cardiac arrests in pediatric intensive care units. Resuscitation 133:25-32
Cashen, Katherine; Reeder, Ron; Dalton, Heidi J et al. (2018) Acquired infection during neonatal and pediatric extracorporeal membrane oxygenation. Perfusion 33:472-482
Berg, Robert A; Sutton, Robert M; Reeder, Ron W et al. (2018) Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation 137:1784-1795
Cashen, Katherine; Reeder, Ron W; Shanti, Christina et al. (2018) Is therapeutic hypothermia during neonatal extracorporeal membrane oxygenation associated with intracranial hemorrhage? Perfusion 33:354-362
Sutton, Robert M; Reeder, Ron W; Landis, William et al. (2018) Chest compression rates and pediatric in-hospital cardiac arrest survival outcomes. Resuscitation 130:159-166
Davila, Sam; Halstead, E Scott; Hall, Mark W et al. (2018) Viral DNAemia and Immune Suppression in Pediatric Sepsis. Pediatr Crit Care Med 19:e14-e22
Muszynski, Jennifer A; Reeder, Ron W; Hall, Mark W et al. (2018) RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med 46:e552-e559
Dalton, Heidi J; Cashen, Katherine; Reeder, Ron W et al. (2018) Hemolysis During Pediatric Extracorporeal Membrane Oxygenation: Associations With Circuitry, Complications, and Mortality. Pediatr Crit Care Med 19:1067-1076
Berger, John T; Villalobos, Michele E; Clark, Amy E et al. (2018) Cognitive Development One Year After Infantile Critical Pertussis. Pediatr Crit Care Med 19:89-97
Basu, Sonali; Holubkov, Richard; Dean, J Michael et al. (2018) PICU Autopsies: Rates, Patient Characteristics, and the Role of the Medical Examiner. Pediatr Crit Care Med 19:1137-1145

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