In response to the NICHD RFA-HD-10-008, the Division of Maternal Fetal Medicine at Stanford University submits this application to participate in the ongoing Maternal Fetal Medicine Units Network. This application represents collaboration between two institutions: Stanford University and Santa Clara Valley Medical Center (SCVMC). The MFM Division at Stanford has a long history of performing prospective clinical trials, many accomplished with SCVMC under the umbrella of the Stanford-Santa Clara Valley Research Collaboration. The MFM Division at Stanford resides in Lucile Packard Children's Hospital (LPCH), and the Divisions of Maternal-Fetal Medicine and Neonatal and Developmental Medicine have a long history of close collaboration, as well. In 1997, this relationship culminated in the establishment of The Charles B. and Ann L. Johnson Center for Pregnancy and Newborn Services, a fully integrated clinical service line for perinatal services as well as neonatalogy and developmental medicine. Stanford has been a member of the Neonatal Research Network (NRN) since 1991, and our joint participation in these Networks would be of tremendous benefit to the execution of clinical protocols. Stanford University is world-renowned for creative research endeavors, and would contribute unique strengths in imaging, genetics, placental function and analysis, genomics and proteomics, pharmacogenomics, infectious disease, and simulation to expand the productivity and diversity of projects available to the MFMU Network. In summary, we bring to the MFMU a large, uniquely diverse patient population, a productive and proven research team, and access to the exceptional programs and expertise available at Stanford University.

Public Health Relevance

The experience and expertise of Stanford University's MFM Division dovetails with the MFMU Network's goals of rigorous evaluation of treatment and management strategies used in the care of pregnant women. The faculty includes an experienced team of board-certified perinatologists with experience and interest in participating in rigorous research protocols. The experience and diversity of these centers will add great value to the MFMU Network.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10HD068268-01
Application #
8081357
Study Section
Special Emphasis Panel (ZHD1-DRG-D (50))
Program Officer
Spong, Catherine
Project Start
2011-04-07
Project End
2016-03-30
Budget Start
2011-04-07
Budget End
2012-03-31
Support Year
1
Fiscal Year
2011
Total Cost
$316,000
Indirect Cost
Name
Stanford University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Chauhan, Suneet P; Weiner, Steven J; Saade, George R et al. (2018) Intrapartum Fetal Heart Rate Tracing Among Small-for-Gestational Age Compared With Appropriate-for-Gestational-Age Neonates. Obstet Gynecol 132:1019-1025
Bloom, Steven L; Belfort, Michael; Saade, George et al. (2016) What we have learned about intrapartum fetal monitoring trials in the MFMU Network. Semin Perinatol 40:307-17
Wapner, Ronald J; Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A et al. (2016) What we have learned about antenatal corticosteroid regimens. Semin Perinatol 40:291-7
Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A; Blackwell, Sean C et al. (2016) Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. N Engl J Med 374:1311-20
Salazar, Ashley; Tolivaisa, Susan; Allard, Donna et al. (2016) What we have learned about best practices for recruitment and retention in multicenter pregnancy studies. Semin Perinatol 40:321-7
Osmundson, Sarah S; Garabedian, Matthew J; Yeaton-Massey, Amanda et al. (2015) Risk factors for classical hysterotomy in twin pregnancies. Obstet Gynecol 125:643-8
Belfort, Michael A; Saade, George R; Thom, Elizabeth et al. (2015) A Randomized Trial of Intrapartum Fetal ECG ST-Segment Analysis. N Engl J Med 373:632-41
Girsen, Anna I; Osmundson, Sarah S; Naqvi, Mariam et al. (2014) Body mass index and operative times at cesarean delivery. Obstet Gynecol 124:684-9