Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HL052016-03
Application #
2229121
Study Section
Clinical Trials Review Committee (CLTR)
Project Start
1994-07-15
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472
Hyacinth, Hyacinth I; Adams, Robert J; Greenberg, Charles S et al. (2015) Effect of Chronic Blood Transfusion on Biomarkers of Coagulation Activation and Thrombin Generation in Sickle Cell Patients at Risk for Stroke. PLoS One 10:e0134193
Hyacinth, Hyacinth I; Adams, Robert J; Voeks, Jenifer H et al. (2014) Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk. Am J Hematol 89:47-51
Hyacinth, Hyacinth I; Gee, Beatrice E; Adamkiewicz, Thomas V et al. (2012) Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia. Cytokine 60:302-8
Kral, Mary C; Brown, Ronald T; Connelly, Mark et al. (2006) Radiographic predictors of neurocognitive functioning in pediatric Sickle Cell disease. J Child Neurol 21:37-44
Lee, Margaret T; Piomelli, Sergio; Granger, Suzanne et al. (2006) Stroke Prevention Trial in Sickle Cell Anemia (STOP): extended follow-up and final results. Blood 108:847-52
Abboud, Miguel R; Cure, Joel; Granger, Suzanne et al. (2004) Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study. Blood 103:2822-6
Adams, Robert J; Brambilla, Donald J; Granger, Suzanne et al. (2004) Stroke and conversion to high risk in children screened with transcranial Doppler ultrasound during the STOP study. Blood 103:3689-94
Hsu, Lewis L; Miller, Scott T; Wright, Elizabeth et al. (2003) Alpha Thalassemia is associated with decreased risk of abnormal transcranial Doppler ultrasonography in children with sickle cell anemia. J Pediatr Hematol Oncol 25:622-8
Kral, Mary C; Brown, Ronald T; Nietert, Paul J et al. (2003) Transcranial Doppler ultrasonography and neurocognitive functioning in children with sickle cell disease. Pediatrics 112:324-31
Miller, S T; Wright, E; Abboud, M et al. (2001) Impact of chronic transfusion on incidence of pain and acute chest syndrome during the Stroke Prevention Trial (STOP) in sickle-cell anemia. J Pediatr 139:785-9

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