Abstract

The specific aims of our Network proposal proceed from localizing genes, to identifying candidate functional DNA sequence variation within these genes, to estimating the contribution of this DNA variation to the risk of EHYT. First, we will use linkage analysis to localize genes contributing to the risk of EHYT in three racial groups: African- Americans from Jackson, MS, Mexican-Americans from Starr County, TX, and Non-Hispanic Whites from Rochester, MN. The proposed linkage analyses will take advantage of the availability of both an extensive array of candidate genes and a large number of anonymous markers throughout the genome. We will use multiple diallelic sequence polymorphisms and cladistic analyses to begin to identify candidate functional sequence variation within a gene contributing to interindividual differences in BP levels and EHYT status. Finally, we will evaluate the ability of the candidate functional DNA sequence variation to predict EHYT status in three racial groups: African-Americans from Jackson, MS, Mexican- Americans from Starr County, TX, and Non-Hispanic Whites from Rochester, MN.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
1U10HL054457-01
Application #
2232821
Study Section
Special Emphasis Panel (ZHL1-CCT-M (F2))
Project Start
1995-09-05
Project End
2000-08-31
Budget Start
1995-09-05
Budget End
1996-08-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Genetics
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Ward-Caviness, Cavin K; Huffman, Jennifer E; Everett, Karl et al. (2018) DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis. Blood 132:1842-1850
Liu, Jiaxuan; Zhao, Wei; Ware, Erin B et al. (2018) DNA methylation in the APOE genomic region is associated with cognitive function in African Americans. BMC Med Genomics 11:43
Kattah, Andrea G; Suarez, Maria L G; Milic, Natasa et al. (2018) Hormone therapy and urine protein excretion: a multiracial cohort study, systematic review, and meta-analysis. Menopause 25:625-634
Rudra, Pratyaydipta; Broadaway, K Alaine; Ware, Erin B et al. (2018) Testing cross-phenotype effects of rare variants in longitudinal studies of complex traits. Genet Epidemiol 42:320-332
Wright, Michelle L; Ware, Erin B; Smith, Jennifer A et al. (2018) Joint Influence of SNPs and DNA Methylation on Lipids in African Americans From Hypertensive Sibships. Biol Res Nurs 20:161-167
Nandakumar, Priyanka; Lee, Dongwon; Richard, Melissa A et al. (2017) Rare coding variants associated with blood pressure variation in 15?914 individuals of African ancestry. J Hypertens 35:1381-1389
Jhun, Min A; Smith, Jennifer A; Ware, Erin B et al. (2017) Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study. Am J Epidemiol 186:1149-1158
Ben-Avraham, Dan; Karasik, David; Verghese, Joe et al. (2017) The complex genetics of gait speed: genome-wide meta-analysis approach. Aging (Albany NY) 9:209-246
Justice, Anne E (see original citation for additional authors) (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 8:14977
Ligthart, Symen; Marzi, Carola; Aslibekyan, Stella et al. (2016) DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol 17:255

Showing the most recent 10 out of 28 publications