Abstract

This Network proposes to carry out five specific aims to localize and characterize the genetic determinant of high BP.
Aim 1 will use robust sibling pair linkage methods in 500 hypertensive sibling pairs in each racial group (a total of 1500 sibling pairs) to localize genes influencing interindividual differences in the occurrence of EHYT.
Aims 2 and 3 will take advantage of previously collected BP and intermediate predictor trait data rom 1488 sibling pairs from the Rochester (MN) Family Heart Study to localize genes contributing to BP and EHYT. The proposed linkage analyses (Aims 1-3) will use both an extensive array of candidate genes and a large number of anonymous markers throughout the genome.
Aim 4 will use multiple diallelic sequence polymorphisms and cladistic analyses within a linked gene to identify haplotypes for further DNA sequencing in order to identify candidate functional DNA sequence variation contributing to interindividual differences in BP level and EHYT status.
Aim 5 will evaluate the ability of candidate functional DNA sequence variation to predict EHYT status in the three racial groups.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HL054464-04
Application #
2771425
Study Section
Special Emphasis Panel (ZHL1-CCT-M (F2))
Project Start
1995-09-05
Project End
2000-08-31
Budget Start
1998-09-11
Budget End
1999-08-31
Support Year
4
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Ward-Caviness, Cavin K; Huffman, Jennifer E; Everett, Karl et al. (2018) DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis. Blood 132:1842-1850
Kattah, Andrea G; Suarez, Maria L G; Milic, Natasa et al. (2018) Hormone therapy and urine protein excretion: a multiracial cohort study, systematic review, and meta-analysis. Menopause 25:625-634
Nandakumar, Priyanka; Lee, Dongwon; Richard, Melissa A et al. (2017) Rare coding variants associated with blood pressure variation in 15?914 individuals of African ancestry. J Hypertens 35:1381-1389
Ibrahim-Verbaas, C A; Bressler, J; Debette, S et al. (2016) GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry 21:189-197
Olfson, E; Saccone, N L; Johnson, E O et al. (2016) Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Mol Psychiatry 21:601-7
Debette, Stéphanie; Ibrahim Verbaas, Carla A; Bressler, Jan et al. (2015) Genome-wide studies of verbal declarative memory in nondemented older people: the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. Biol Psychiatry 77:749-63
Day, Felix R (see original citation for additional authors) (2015) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nat Genet 47:1294-1303
Verhaaren, Benjamin F J; Debette, Stéphanie; Bis, Joshua C et al. (2015) Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI. Circ Cardiovasc Genet 8:398-409
Kraja, Aldi T; Chasman, Daniel I; North, Kari E et al. (2014) Pleiotropic genes for metabolic syndrome and inflammation. Mol Genet Metab 112:317-38
Non, Amy L; Gravlee, Clarence C; Mulligan, Connie J (2012) Education, genetic ancestry, and blood pressure in African Americans and Whites. Am J Public Health 102:1559-65

Showing the most recent 10 out of 23 publications