Abstract

The Utah staff supported by this specific grant will perform three functions: l. Serve as the Utah Field Center to recruit and examine 625 participants from the Utah sample of the NHLBI Family Heart Study. 2. Serve as the Network Administration Center for all 9 collaborating groups. 3. Provide advance studies and analyses of a """"""""Utah Supplemental Sample"""""""" using previously collected DNA samples and extensive phenotype data already entered into computer for 793 persons in 135 Utah families with hypertension (including 245 HBP sibpairs, plus normotensive relatives and spouses).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HL054471-03
Application #
2519493
Study Section
Special Emphasis Panel (ZHL1-CCT-M (F2))
Project Start
1995-09-05
Project End
2000-08-31
Budget Start
1997-09-01
Budget End
1998-08-31
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Wild, Philipp S; Felix, Janine F; Schillert, Arne et al. (2017) Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. J Clin Invest 127:1798-1812
Steenstrup, Troels; Kark, Jeremy D; Verhulst, Simon et al. (2017) Telomeres and the natural lifespan limit in humans. Aging (Albany NY) 9:1130-1142
Nandakumar, Priyanka; Lee, Dongwon; Richard, Melissa A et al. (2017) Rare coding variants associated with blood pressure variation in 15?914 individuals of African ancestry. J Hypertens 35:1381-1389
Selvaraj, Senthil; Djoussé, Luc; Aguilar, Frank G et al. (2017) Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function: From the HyperGEN Study. J Am Coll Cardiol 70:715-724
Wang, Heming; Choi, Yoonha; Tayo, Bamidele et al. (2017) Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Genet Epidemiol 41:122-135
Taylor, Jacquelyn Y; Schwander, Karen; Kardia, Sharon L R et al. (2016) A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. Sci Rep 6:18812
Olfson, E; Saccone, N L; Johnson, E O et al. (2016) Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Mol Psychiatry 21:601-7
Selvaraj, Senthil; Martinez, Eva E; Aguilar, Frank G et al. (2016) Association of Central Adiposity With Adverse Cardiac Mechanics: Findings From the Hypertension Genetic Epidemiology Network Study. Circ Cardiovasc Imaging 9:
Aguilar, Frank G; Selvaraj, Senthil; Martinez, Eva E et al. (2016) Archeological Echocardiography: Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN Study. Echocardiography 33:386-97
Mangino, Massimo; Christiansen, Lene; Stone, Rivka et al. (2015) DCAF4, a novel gene associated with leucocyte telomere length. J Med Genet 52:157-62

Showing the most recent 10 out of 64 publications