The University of Wisconsin-Madison Regional Coordinating Stroke Center (UW RCC) wiii support the regional organization of national NIH Stroke Trials. This will include prevention, treatment, and recovery. This RCC infrastructure will be based on the already established Wisconsin Network for Health Research (WiNHR), an NIH-sponsored research consortium including academic, urban, rural, and underserved and health disparity populations. It includes four major health systems with a total of 12.7 million outpatient visits per year. In addition to the WiNHR network, 26 additional health entities have been recruited for participation in this RCC including Native American communities. Experience in data correlation, study coordination, and CTSA infrastructure, will assure innovative training and success in the effort. Our experience in collaborative research will foster translation of preclinical and clinical trials, as well as a proven ability to recruit stroke patients. This integration of neurosurgery, vascular neurology, neurosurgery, interventional neuroradiology, neuro-intensive care, stroke rehabilitation, emergency medicine, pediatric neurology, and innovative neuro- imaging will enhance productivity. Through investigator initiated stroke research, training and trial design, we propose to enhance the overall national programs in stroke research rather than simply manage trials. Our plan is: 1) to improve the pre-hospital plan for acute stroke through collaborations with satellite hospitals. 2) To utilize established networks such as the Wisconsin Network for Health Research (WiNHR), Collaborative Center for Health Equity (CCHE), Community Health Connections (CHC), and expanding Telestroke never for enjoyment of our diverse patient population in clinical trials. 3) To educate providers across the care spec aim at the pre-hospital, satellite hospital, and tertiary referral hospital setting. 4) To improve clinical, IRB,-and data management infrastructure for satellite hospitals through trial protocol and data management experts available within existing infrastructure at the University of Wisconsin including the Institute for Collaborative and Transitional Research (ICTR), Office of Clinical Trials (OCT), and the Mobile Research Team (MRT).

Public Health Relevance

Stroke is a disabling, often fatal complex disorder burdening public health expenditures and devastating personal and family impacts. Stroke impact worsens with the projected rise in the proportion of elderly in the US over the next few decades. This regional coordinating center will be an integral component in driving collaborations to answer the highest priority scientific questions for advancing stroke prevention, treatment and recovery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10NS086533-05
Application #
9315228
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Vivalda, Joanna
Project Start
2013-09-25
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2019-07-31
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715