The Fire Department of the City of New York (FDNY) responded to the World Trade Center (WTC) on 9/11/01 &despite numerous injuries &incredible losses (343 FDNY rescue workers died that day) continued to provide rescue, recovery &clean-up services from 9/11/01 until the site officially closed on 6/2002. During this effort, nearly the entire FDNY rescue workforce was exposed. In October 2001, the CDC funded the FDNY Bureau of Health Services'WTC Medical Monitoring Program to provide immediate medical monitoring for FDNY rescue workers (Firefighters, EMS workers &Officers;incumbents &recent retirees). The team at FDNY submitting this Clinical Center Proposal has been the Clinical Center for the existing FDNY-WTC Medical Monitoring Program (CC-FDNY-WTC) Our response to RFA-OH-04-004 builds on the results of our successful FDNY Bureau of Health Services'WTC Medical Monitoring Program. Continuation of the current FDNY Data &Coordinating Center is an essential part of the overall program for the long-term medical monitoring of FDNY rescue workers (incumbent &retirees) who responded to &worked during the World Trade Center attack, rescue &recovery site. Based on our prior work in collecting, analyzing and publishing this data while maintaining patient privacy and confidentiality as well as the strength of our collaborations with the many other WTC investigators, we believe we are best suited for the continuation of this program. FDNY rescue personnel also agree as over 84% of those eligible have come to us for their medical monitoring and to date we have evaluated (CC activity) and analyzed (DCC activity) 12,766 FDNY rescue workers. Continued medical monitoring and clinical services remains essential to our patients as they continue to suffer from respiratory and mental health problems.

Agency
National Institute of Health (NIH)
Institute
National Institute for Occupational Safety and Health (NIOSH)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10OH008243-05S1
Application #
7920576
Study Section
Special Emphasis Panel (ZOH1-SPC (04))
Program Officer
Fleming, Roy M
Project Start
2004-07-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2010-06-30
Support Year
5
Fiscal Year
2009
Total Cost
$23,498,224
Indirect Cost
Name
New York City Fire Department
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
11201
Weiden, Michael D; Kwon, Sophia; Caraher, Erin et al. (2015) Biomarkers of World Trade Center Particulate Matter Exposure: Physiology of Distal Airway and Blood Biomarkers that Predict FEV? Decline. Semin Respir Crit Care Med 36:323-33
Schenck, Edward J; Echevarria, Ghislaine C; Girvin, Francis G et al. (2014) Enlarged pulmonary artery is predicted by vascular injury biomarkers and is associated with WTC-Lung Injury in exposed fire fighters: a case-control study. BMJ Open 4:e005575
Tsukiji, Jun; Cho, Soo Jung; Echevarria, Ghislaine C et al. (2014) Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study. Biomarkers 19:159-65
Cho, Soo Jung; Echevarria, Ghislaine C; Kwon, Sophia et al. (2014) One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure. Respir Med 108:162-70
Cho, Soo Jung; Nolan, Anna; Echevarria, Ghislaine C et al. (2013) Chitotriosidase is a biomarker for the resistance to World Trade Center lung injury in New York City firefighters. J Clin Immunol 33:1134-42
Weiden, Michael D; Naveed, Bushra; Kwon, Sophia et al. (2013) Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters. Eur Respir J 41:1023-30
Kwon, Sophia; Weiden, Michael D; Echevarria, Ghislaine C et al. (2013) Early elevation of serum MMP-3 and MMP-12 predicts protection from World Trade Center-lung injury in New York City Firefighters: a nested case-control study. PLoS One 8:e76099
Aldrich, Thomas K; Ye, Fen; Hall, Charles B et al. (2013) Longitudinal pulmonary function in newly hired, non-World Trade Center-exposed fire department City of New York firefighters: the first 5 years. Chest 143:791-797
Weiden, Michael D; Naveed, Bushra; Kwon, Sophia et al. (2012) Comparison of WTC dust size on macrophage inflammatory cytokine release in vivo and in vitro. PLoS One 7:e40016
Naveed, Bushra; Weiden, Michael D; Kwon, Sophia et al. (2012) Metabolic syndrome biomarkers predict lung function impairment: a nested case-control study. Am J Respir Crit Care Med 185:392-9

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