There are enormous gaps in the information available to the public about the effects of their drugs, and in the application of that information to optimize medication use. AHRQ's Centers for Education and Research on Therapeutics (CERTs) program offers the opportunity to address many of these deficits. To address these gaps, this application from the University of Pennsylvania (UPenn) proposes to: 1.Continue the development of the PennCERT with a coordinated infrastructure, including: a. Logistical support, including faculty time and core staff; b. Governance, including regular coordination, business meetings, and programmatic coordination, including linkage of the pharmacoepidemiology skills of the Center for Clinical Epidemiology and Biostatistics with the pharmacoeconomics skills of the Leonard Davis Institute of Health Economics; the experience in patient-oriented research of the General Clinical Research Center; basic science laboratories interested in evaluating the molecular mechanisms of drug effects, from the Center for Experimental Therapeutics and elsewhere; and the skills of social science researchers elsewhere the University of Pennsylvania; c. A regularly scheduled educational conference series; d. Active participation in the national network of CERTs; e. A mini-grant research program that funds small studies addressing relevant therapeutic questions as well as pilot studies that support R01 applications; and f. Maintenance of a series of data resources, accessible to investigators from the PennCERT and other CERTs; 2. Conduct research to improve the underlying evidence base for decisions about the use and effects of anti-infective drugs; 3. Implement and evaluate interventions aimed at improving the use of anti-infectives in outpatient and inpatient settings, locally and nationally; 4. Conduct an extensive education program, including: a. a Masters in Clinical Epidemiology (MSCE) and PhD pharmacoepidemiology fellowship training program; b. opportunities for MSCE and PhD students in epidemiology and biostatistics to use existing in-house databases to answer new questions, to participate in ongoing research, and to develop new research projects; c. courses for university physicians, housestaff, and nurses; d. ourses for medical students; e. a new degree credit course in infectious disease epidemiology; and f. a new degree credit course in pharmacoepidemiology research methods. 5. Organize and formally disseminate the results of our work, consisting of publications and presentations targeting: a. for the Scientific/Professional community; b. the FDA, AHRQ, other CERTs, etc.; and c. the public, building on the dissemination program of the Leonard Davis Institute of Health Economics.

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Research Demonstration--Cooperative Agreements (U18)
Project #
5U18HS010399-07
Application #
7122863
Study Section
Special Emphasis Panel (ZHS1-HSR-F (01))
Program Officer
Randhawa, Gurvaneet
Project Start
2000-09-01
Project End
2007-09-29
Budget Start
2006-09-30
Budget End
2007-09-29
Support Year
7
Fiscal Year
2006
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hafkin, J S; Osborn, M K; Localio, A R et al. (2014) Incidence and risk factors for incomplete HBV DNA suppression in HIV/HBV-co-infected patients initiating tenofovir-based therapy. J Viral Hepat 21:288-96
Newland, Jason G; Gerber, Jeffrey S; Weissman, Scott J et al. (2014) Prevalence and characteristics of antimicrobial stewardship programs at freestanding children's hospitals in the United States. Infect Control Hosp Epidemiol 35:265-71
Vinnard, Christopher; Linkin, Darren R; Localio, A Russell et al. (2013) Effectiveness of interventions in reducing antibiotic use for upper respiratory infections in ambulatory care practices. Popul Health Manag 16:22-7
M'ikanatha, Nkuchia M; Dettinger, Lisa A; Perry, Amanda et al. (2012) Culturing stool specimens for Campylobacter spp., Pennsylvania, USA. Emerg Infect Dis 18:484-7
Newman, Ross E; Hedican, Erin B; Herigon, Joshua C et al. (2012) Impact of a guideline on management of children hospitalized with community-acquired pneumonia. Pediatrics 129:e597-604
Forde, K A; Haynes, K; Troxel, A B et al. (2012) Risk of myocardial infarction associated with chronic hepatitis C virus infection: a population-based cohort study. J Viral Hepat 19:271-7
Lo Re 3rd, Vincent; Teal, Valerie; Localio, A Russell et al. (2011) Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study. Ann Intern Med 155:353-60
Strom, Brian L; Schinnar, Rita; Center for Education and Research on Therapeutics, University of Pennsylvania (2011) Evaluating health information technology's clinical effects. LDI Issue Brief 16:1-4
Rattanaumpawan, Pinyo; Tolomeo, Pam; Bilker, Warren B et al. (2011) A clinical prediction rule for fluoroquinolone resistance in healthcare-acquired gram-negative urinary tract infection. Infect Control Hosp Epidemiol 32:1124-6
Haynes, Kevin; Bilker, Warren B; Tenhave, Tom R et al. (2011) Temporal and within practice variability in the health improvement network. Pharmacoepidemiol Drug Saf 20:948-55

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