Abstract

Our proposal for a Center for Translational Research in Human Immunology and Biodefense gathers investigators from different backgrounds, yet unified through their interest in the biology of dendritic cells (DCs) and harnessing them to make novel vaccines. As we planned this Center, we identified experts that would synergize to provide the best possible program on the topic of Harnessing Human DC Subsets for Improved Mucosal Vaccines. Given the breadth of the topic, we'should expect to identify gaps in the repertoire of collective expertise. The objectives of these Pilot Projects will be 1) to fill these knowledge gaps and expand the discoveries made in the Center and 2) to attract, to the field of human immunology, investigators who have proven to be outstanding contributors to basic immunology and to fields that apply to Technology Development. The five years of the Center Cycle will permit us to support up to five Pilot Projects. These projects will be financed for up to two years.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AI057234-06
Application #
7696465
Study Section
Special Emphasis Panel (ZAI1-KS-I (J3))
Project Start
2009-05-01
Project End
2014-04-30
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
6
Fiscal Year
2009
Total Cost
$195,020
Indirect Cost

  Institution

Name
Baylor Research Institute
Department
Type
DUNS #
145745022
City
Dallas
State
TX
Country
United States
Zip Code
75204

  Publications

Athale, Shruti; Banchereau, Romain; Thompson-Snipes, LuAnn et al. (2017) Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets. Sci Transl Med 9:
Todorova, Biliana; Salabert, Nina; Tricot, Sabine et al. (2017) Fibered Confocal Fluorescence Microscopy for the Noninvasive Imaging of Langerhans Cells in Macaques. Contrast Media Mol Imaging 2017:3127908
Silvin, Aymeric; Yu, Chun I; Lahaye, Xavier et al. (2017) Constitutive resistance to viral infection in human CD141+ dendritic cells. Sci Immunol 2:
Yoshimatsu, Gumpei; Kunnathodi, Faisal; Saravanan, Prathab Balaji et al. (2017) Pancreatic ?-Cell-Derived IP-10/CXCL10 Isletokine Mediates Early Loss of Graft Function in Islet Cell Transplantation. Diabetes 66:2857-2867
Mathew, Anuja (2017) Humanized mouse models to study human cell-mediated and humoral responses to dengue virus. Curr Opin Virol 25:76-80
Yin, Wenjie; Gorvel, Laurent; Zurawski, Sandra et al. (2016) Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells. EBioMedicine 5:46-58
Blohmke, Christoph J; Darton, Thomas C; Jones, Claire et al. (2016) Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. J Exp Med 213:1061-77
Kovats, S; Turner, S; Simmons, A et al. (2016) West Nile virus-infected human dendritic cells fail to fully activate invariant natural killer T cells. Clin Exp Immunol 186:214-226
Schmitt, Nathalie; Liu, Yang; Bentebibel, Salah-Eddine et al. (2016) Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans. Cell Rep 16:1082-1095
Raymond, Donald D; Stewart, Shaun M; Lee, Jiwon et al. (2016) Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med 22:1465-1469

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