This grant represents an attempt to understand in a systematic way, the various hormones and growth factors which control the growth and metabolism of lens cells in culture.
The specific aims of the research are: 1) To study external signals that modify lens cell proliferation; 2) To obtain information on the nature of surface receptors on lens cells; 3) To investigate the primary biological response elicited by growth factors; 4) To look at possible models for the transfer of information across the cell membrane; 5) The use of genetics to approach the mechanism of action of growth factors. It is felt that this molecular approach to growth regulation using defined external signals should yield important information on the problem of cataractogenesis.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY005691-03A1
Application #
3261079
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1987-05-01
Project End
1990-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Medicine
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Murphy, C J; Foster, B A; Mannis, M J et al. (1993) Defensins are mitogenic for epithelial cells and fibroblasts. J Cell Physiol 155:408-13