The long-term objective of this core is to provide investigators interested in environmental lung disease the resources and technical expertise required to conduct in vivo mechanistic studies in mice. The following core services will be provided: 1) importation and exportation of mice, 2) breeding of wild type mice for mechanistic studies, 3) breeding and genotying of genetically manipulated mouse lines for use in mechanistic studies, 4) development of allergic mice using both acute and chronic sensitization/challenge protocols, 5) exposure of animals to model environmental pollutants, 6) treatment interventions to test the efficacy, toxicity, and mechanisms of action of novel therapies, and 7) physiological phenotyping of mice after the induction of environmental lung disease for evaluation of airway resistance, compliance, and airway hyperresponsiveness to methacholine. This core supports the mission of NIAID to study genetic and environmental interactions as they relate to environmental lung disease. Mechanistic studies in animals, particularly the use of genetically manipulated mice, is essential for the development of new therapies to improve public health.
| Hua, Xiaoyang; Naselsky, Warren C; Jania, Corey M et al. (2016) Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice. Ann Otol Rhinol Laryngol 125:290-6 |
| Hernandez, Michelle L; Mills, Katherine; Almond, Martha et al. (2015) IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers. J Allergy Clin Immunol 135:379-85 |
| Aleman, Maria M; Kesic, Matthew J; Mills, Katherine H et al. (2015) The IL-1 axis is associated with airway inflammation after O3 exposure in allergic asthmatic patients. J Allergy Clin Immunol 136:1099-101.e2 |
| Kang, Min-Jong; Yoon, Chang Min; Kim, Bo Hye et al. (2015) Suppression of NLRX1 in chronic obstructive pulmonary disease. J Clin Invest 125:2458-62 |
| Aleman, Maria M; Mills, Katherine; Almond, Martha et al. (2015) Reply: To PMID 25195169. J Allergy Clin Immunol 135:836-7 |
| Wu, Weidong; Wages, Phillip A; Devlin, Robert B et al. (2015) SRC-mediated EGF receptor activation regulates ozone-induced interleukin 8 expression in human bronchial epithelial cells. Environ Health Perspect 123:231-6 |
| Bennett, William D; Alexis, Neil E; Almond, Martha et al. (2014) Effect of inhaled endotoxin on mucociliary clearance and airway inflammation in mild smokers and nonsmokers. J Aerosol Med Pulm Drug Deliv 27:459-65 |
| Wu, Weidong; Muller, Robin; Berhane, Kiros et al. (2014) Inflammatory response of monocytes to ambient particles varies by highway proximity. Am J Respir Cell Mol Biol 51:802-9 |
| Fry, Rebecca C; Rager, Julia E; Bauer, Rebecca et al. (2014) Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects. Am J Physiol Lung Cell Mol Physiol 306:L1129-37 |
| Brickey, Willie June (2013) Expression profiling to identify candidate genes associated with allergic phenotypes. Methods Mol Biol 1032:287-95 |
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