The overall research aim of the Amazonian International Center of Excellence in Malaria Research is to organize a comprehensive approach to understanding the biological features of Amazonian malaria towards the ultimate goal of regional control and elimination of Plasmodium falciparum and P. vivax. While in the past the Amazonian ICEMR focused primarily on P. vivax because of its greater impact in the region, given recent developments in both Brazil and Peru, P. falciparum will also be a focus of our work. At the national level in Brazil, the national malaria control program has made P. falciparum a primary focus of elimination efforts, as P. falciparum malaria remains highly prevalent in the Juru Valley in western Brazilian Amazonia. In Peru, after the cessation of Global Fund-supported malaria control efforts in 2010, P. falciparum has reemerged as an important public health threat. The Amazonian ICEMR's recent meetings with the Loreto Ministry of Health witnessed the high level of concern about this re-emergence and the Ministry's interest in harnessing the Amazonian ICEMR's research strengths to addressing this emergent and timely issue. Overall, we anticipate that the lessons learned will contribute towards the audacious goal of global malaria eradication. The Amazonian ICEMR has 5 epidemiologically distinct malaria-endemic sites in Brazil and Peru. Project 1 focuses on malaria epidemiology and takes multidisciplinary approaches to study distinct transmission patterns in the Brazilian and Peruvian malaria-endemic sites using socio-demographic analysis, molecular epidemiology and genomics, and mathematical modeling to integrate all three ICEMR Projects, including Project 2, which focuses on vector ecology and transmission biology, and Project 3, which focuses on immunological mechanisms of asymptomatic parasitemia and clinical immunity, and to discover biosignatures of clinically immune (asymptomatic parasitemia) vs non-immune (acute, symptomatic malaria). Our long-term goal is to develop the scientific underpinnings of novel elimination strategies to be deployed in Amazonia, with broad generalizability to other malaria-endemic regions. This proposed Center therefore takes on a comprehensive approach to malaria research in the Peruvian and Brazilian Amazon, which will be used to inform Ministries of Health in Brazil and Peru, and officials of the Pan American Health Organization and the Amazonian Malaria Initiative, of new approaches to develop malaria elimination policies based on scientific data.
The Amazonia ICEMR focuses discovering underlying principles and developing new tools to go beyond conventional malaria control activities towards regional malaria elimination. This project will obtain field-based epidemiological and entomology/ecology data and combined this information with laboratory-based experimental mosquito infections and immunology experiments on which mathematical models of malaria transmission can be used to design new intervention strategies.
|Rodrigues, Priscila T; Valdivia, Hugo O; de Oliveira, Thais C et al. (2018) Human migration and the spread of malaria parasites to the New World. Sci Rep 8:1993|
|Moreno, Marta; Tong-Rios, Carlos; Orjuela-Sanchez, Pamela et al. (2018) Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon. ACS Infect Dis 4:541-548|
|Prussing, Catharine; Moreno, Marta; Saavedra, Marlon P et al. (2018) Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru. Malar J 17:86|
|Martin, Thomas C S; Vinetz, Joseph M (2018) Asymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination. Malar J 17:89|
|Junqueira, Caroline; Barbosa, Camila R R; Costa, Pedro A C et al. (2018) Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med 24:1330-1336|
|Cowell, Annie N; Valdivia, Hugo O; Bishop, Danett K et al. (2018) Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing. Genome Med 10:52|
|Schrum, Jacob E; Crabtree, Juliet N; Dobbs, Katherine R et al. (2018) Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity. J Immunol 200:1243-1248|
|White, Sara E; Harvey, Steven A; Meza, Graciela et al. (2018) Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study. Malar J 17:179|
|Hirako, Isabella Cristina; Assis, Patrícia Aparecida; Hojo-Souza, Natália Satchiko et al. (2018) Daily Rhythms of TNF? Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle. Cell Host Microbe 23:796-808.e6|
|Prussing, Catharine; Bickersmith, Sara A; Moreno, Marta et al. (2018) Nyssorhynchus dunhami: bionomics and natural infection by Plasmodium falciparum and P. vivax in the Peruvian Amazon. Mem Inst Oswaldo Cruz 113:e180380|
Showing the most recent 10 out of 69 publications