The objectives of the Administrative Core (Core A) are to provide a robust infrastructure and communication network that promotes program faculty Interactions and data disseminafion to achieve the overall short and long-term goals of the research program. Core A is the prime decision making body for the program. Core A will: a) provide guidance and leadership on administrative and financial matters, b) facilitate communication among the research groups, cores and NIAID, c) promote scientific interactions, data sharing and discussions, d) disseminate information to the scientific community and public using the SQL database and NIH Bloinfonnatics Centers, e) host seminars and yearly meefings, and f) ensure regulatory compliance and safety for all projects and cores. Success of the Cooperative Agreement is heavily dependent upon organized communication and the exchange of time-sensitive samples and complex datasets between the Research Projects and Cores. Core A is the pipeline connecting all Projects and Cores, tasked with providing the essenfial leadership and infrastructure that provides direction, oversight and quality control for the individual and interdependent activities of each project and core, ensuring maximum collaboration, transparent use of program resources and information exchange within our research community. This is accomplished in four broad aims: administrative and fiscal management, communication management, scientific oversight, and web-based education and outreach.

Public Health Relevance

Core A is assigned the complex task of overseeing the fiscal management, dissemination of detailed data sets between the Projects and Cores, integrating concepts across projects, enabling communication, and ensuring outreach to the public. The Core will leverage the expertise of each member ofthe program to expedite discovery and achievement of the research goals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI107810-03
Application #
8849360
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
2016-05-31
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
3
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Graham, Rachel L; Deming, Damon J; Deming, Meagan E et al. (2018) Evaluation of a recombination-resistant coronavirus as a broadly applicable, rapidly implementable vaccine platform. Commun Biol 1:179
Oishi, Kohei; Yamayoshi, Seiya; Kozuka-Hata, Hiroko et al. (2018) N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X. Cell Rep 24:851-860
Oishi, Kohei; Yamayoshi, Seiya; Kawaoka, Yoshihiro (2018) Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast. Virology 516:71-75
Johnson, Bryan A; Graham, Rachel L; Menachery, Vineet D (2018) Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses. Virology 517:30-37
Halfmann, Peter; Hill-Batorski, Lindsay; Kawaoka, Yoshihiro (2018) The Induction of IL-1? Secretion Through the NLRP3 Inflammasome During Ebola Virus Infection. J Infect Dis 218:S504-S507
Gallichotte, Emily N; Dinnon 3rd, Kenneth H; Lim, Xin-Ni et al. (2017) CD-loop Extension in Zika Virus Envelope Protein Key for Stability and Pathogenesis. J Infect Dis 216:1196-1204
Menachery, Vineet D; Graham, Rachel L; Baric, Ralph S (2017) Jumping species-a mechanism for coronavirus persistence and survival. Curr Opin Virol 23:1-7
Hsia, Hung-Ching; Stopford, Charles M; Zhang, Zhigang et al. (2017) Signal transducer and activator of transcription 3 (Stat3) regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection. J Leukoc Biol 101:1053-1064
Schifano, Jason M; Corcoran, Kathleen; Kelkar, Hemant et al. (2017) Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus. J Virol 91:
Corcoran, Kathleen; Sherrod, Carly J; Perkowski, Ellen F et al. (2017) Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation. Genome Announc 5:

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