Core of the Antiviral Drug Discovery and Development Center (ADSC) will provide a key role in leadership, communication, coordination and oversight ofthe projects and cores, and stimulate collaboration and synergy between the projects. Operationally, it is in charge of fiscal and contractual management of the center and will plan and implement activities, such as meetings of the Executive Committee (EC), External Scientific Advisory Board (EAB), and an annual meeting of all projects and cores. In addition, it will manage the inter-institutional cooperative agreements. The core is also responsible for managing the solicitation and review of Supplemental Research Projects applications, such as those for additional product development and support for IND-enabling studies. Finally, the core will facilitate dissemination of progress and discoveries to the public.

Public Health Relevance

The Administrative Core will provide information and assistance to Antiviral Drug Discovery and Development Center project investigators who are developing potential therapies for emerging infections such as West Nile virus and influenza. The Core will also assist with preparing reports and publications that will allow public access to data and results that are collected as part of the scientific research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI109680-05
Application #
9542488
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Beanan, Maureen J
Project Start
Project End
Budget Start
2018-03-01
Budget End
2019-02-28
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Carpentier, Kathryn S; Morrison, Thomas E (2018) Innate immune control of alphavirus infection. Curr Opin Virol 28:53-60
McCarthy, Mary K; Davenport, Bennett J; Reynoso, Glennys V et al. (2018) Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment. JCI Insight 3:
Shin, Jin Soo; Jung, Eunhye; Kim, Meehyein et al. (2018) Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro. Viruses 10:
Johnson, Britney; VanBlargan, Laura A; Xu, Wei et al. (2018) Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity 48:487-499.e5
Agostini, Maria L; Andres, Erica L; Sims, Amy C et al. (2018) Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio 9:
Pryke, Kara M; Abraham, Jinu; Sali, Tina M et al. (2017) A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio 8:
McCarthy, Mary K; Morrison, Thomas E (2017) Persistent RNA virus infections: do PAMPS drive chronic disease? Curr Opin Virol 23:8-15
Sheahan, Timothy P; Sims, Amy C; Graham, Rachel L et al. (2017) Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med 9:
Jones, Jennifer E; Long, Kristin M; Whitmore, Alan C et al. (2017) Disruption of the Opal Stop Codon Attenuates Chikungunya Virus-Induced Arthritis and Pathology. MBio 8:
Haese, Nicole N; Broeckel, Rebecca M; Hawman, David W et al. (2016) Animal Models of Chikungunya Virus Infection and Disease. J Infect Dis 214:S482-S487

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