Abstract

The COVID-19 pandemic is the most important health challenge to the US population within a century. Most epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults. Inadequate information regarding the infection burden in children is available, especially in the context of households that are prospectively monitored with repetitive testing. This information is critical to determine the silent and symptomatic infection rate in children. The NIAID-supported Human Epidemiology and Response to SARS- CoV-2 (HEROS) survey study is designed to fill this gap.

Public Health Relevance

The study has enrolled and prospectively observes eligible children that are current participants in NIH-funded pediatric research studies and their household members. HEROS currently involves approximately 1,300 households and approximately 4,000 enrolled household members (children and adults). This supplement is essential to addressing the aims of the project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19AI118610-06S3
Application #
10330073
Study Section
Program Officer
Kelly, Halonna R
Project Start
2021-02-11
Project End
2021-05-31
Budget Start
2021-02-15
Budget End
2021-05-31
Support Year
6
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Janssens, Sylvie; Schotsaert, Michael; Manganaro, Lara et al. (2018) FACS-Mediated Isolation of Neuronal Cell Populations From Virus-Infected Human Embryonic Stem Cell-Derived Cerebral Organoid Cultures. Curr Protoc Stem Cell Biol :e65
Thézé, Julien; Li, Tony; du Plessis, Louis et al. (2018) Genomic Epidemiology Reconstructs the Introduction and Spread of Zika Virus in Central America and Mexico. Cell Host Microbe 23:855-864.e7
Patil, Veena S; Madrigal, Ariel; Schmiedel, Benjamin J et al. (2018) Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis. Sci Immunol 3:
Manganaro, Lara; Hong, Patrick; Hernandez, Matthew M et al. (2018) IL-15 regulates susceptibility of CD4+ T cells to HIV infection. Proc Natl Acad Sci U S A 115:E9659-E9667
Andrade, Paulina; Coloma, Josefina; Harris, Eva (2018) ELISPOT-Based ""Multi-Color FluoroSpot"" to Study Type-Specific and Cross-Reactive Responses in Memory B Cells after Dengue and Zika Virus Infections. Methods Mol Biol 1808:151-163
Wang, Daifeng; Liu, Shuang; Warrell, Jonathan et al. (2018) Comprehensive functional genomic resource and integrative model for the human brain. Science 362:
Michlmayr, Daniela; Pak, Theodore R; Rahman, Adeeb H et al. (2018) Comprehensive innate immune profiling of chikungunya virus infection in pediatric cases. Mol Syst Biol 14:e7862
Tsai, Wen-Yang; Youn, Han Ha; Tyson, Jasmine et al. (2018) Use of Urea Wash ELISA to Distinguish Zika and Dengue Virus Infections. Emerg Infect Dis 24:1355-1359
Young, George R; Terry, Sandra N; Manganaro, Lara et al. (2018) HIV-1 Infection of Primary CD4+ T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements. J Virol 92:
Tan, Yi; Pickett, Brett E; Shrivastava, Susmita et al. (2018) Differing epidemiological dynamics of Chikungunya virus in the Americas during the 2014-2015 epidemic. PLoS Negl Trop Dis 12:e0006670

Showing the most recent 10 out of 42 publications