Our Center seeks to usehigh-throughputpro?lingtechnologiestodeveloppredictivemodelsofLassafever and Ebola virusdiseaseatasystemsbiologylevel.Thesuccessofthismissionisdependentontheunique cohortsandinnovativepro?lingmethods,thecombinationofwhichwillresultinauniqueandpowerfuldata set.Inthiscontext,theoverallmissionoftheDataManagementandBioinformaticsCore(DMBC)istoensure that the Center utilizes best practices for data provenance, analysis, management, and dissemination throughoutthedatalifecycle.Toaccomplishthismission,wewillpromotetherobustcollectionandanalysis oftheprimarydata,developaframeworkforreproduciblework?owsthatcanbeusedacrosstheCenter,and maximize dissemination and reuse of Center-generated data and tools. OurmissionwillbeaccomplishedthroughthecompletionofthreeSpeci?cAims.
Aim1 focusesonaccurately capturing clinical and laboratory data, and then reproducibly processing them using robustwork?owtools.
This aim describesakey,foundationalfunctionthatiscriticalforthesuccessoftheCenter.
Aim2 focuseson dissemination of Center-generated resources according to FAIR principles - Findable, Accessible, Interoperable,andReusable.ThisworkwillensurethattheimpactofourCenterextendsbeyondourteam?s stated analysis plan, and it leverages our extensive work building tools for e?ective data and software dissemination.
Aim 3 focuses on directly engagingthecommunityincollaborationswithavarietyofgroups with complementary skills and assets. This work leverages the principlethatcollaborativeplatformsenable discoveries that would not be possible through individual investigations. Overall,webelievethatthisplanfortheDMBCo?ersabroadandsolidfoundationonwhichourCenter?sdata generation, data modeling, and biological discovery activities can build.
|Siddle, Katherine J; Eromon, Philomena; Barnes, Kayla G et al. (2018) Genomic Analysis of Lassa Virus during an Increase in Cases in Nigeria in 2018. N Engl J Med 379:1745-1753|
|Saphire, Erica Ollmann; Schendel, Sharon L; Fusco, Marnie L et al. (2018) Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell 174:938-952.e13|
|Holmes, Edward C; Rambaut, Andrew; Andersen, Kristian G (2018) Pandemics: spend on surveillance, not prediction. Nature 558:180-182|
|Suchard, Marc A; Lemey, Philippe; Baele, Guy et al. (2018) Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10. Virus Evol 4:vey016|
|Gunn, Bronwyn M; Yu, Wen-Han; Karim, Marcus M et al. (2018) A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host Microbe 24:221-233.e5|
|Saphire, Erica Ollmann; Schendel, Sharon L; Gunn, Bronwyn M et al. (2018) Antibody-mediated protection against Ebola virus. Nat Immunol 19:1169-1178|
|Rambaut, Andrew; Drummond, Alexei J; Xie, Dong et al. (2018) Posterior Summarization in Bayesian Phylogenetics Using Tracer 1.7. Syst Biol 67:901-904|