The parent grant was awarded as a HEAL Initiative award, specifically as part of the Back Pain Consortium (BACPAC) Research Program (FOA: AR19-026). The current proposal will supplement the University of Michigan Mechanistic Research Center (UM MRC; U19 AR076734-01). The UM MRC aims to perform interventional response phenotyping in a cohort of chronic low back pain (cLBP) patients. Interventional response phenotyping describes the critical need to attain high quality information on each participant regarding to which drug and non-drug therapies they do and do not respond. This need extends to psychotherapeutic interventions, which are often used for the treatment of cLBP. This proposal will provide one year of support for the candidate to attain focused training in clinical pain research, including exploring differential response to psychotherapeutic interventions. Successful completion of this work will provide the HEAL Initiative with an extensive systematic literature review examining baseline phenotypic factors that predict differential responsiveness to the some of the most commonly used psychotherapeutic interventions for cLBP. The training plan will allow the candidate to: 1) understand the theory underlying and execution of some of the most commonly used psychotherapeutic interventions for cLBP; 2) develop expertise in phenotypic differences among patients with cLBP that might impact interventional efficacy; and 3) understand the patient and provider experience in order to promote the development and implementation of effective interventions for cLBP. The candidate will work with the PIs of the parent grant, Drs. Afton Hassett and Daniel Clauw, to complete this comprehensive training and research plan. Combined with the rich environment of the University of Michigan, this award will provide focused training to establish a unique niche of expertise and an independent research program focused on intervention modification, development, and evaluation for chronic pain patients with a history of trauma, the candidate?s primary area of interest.

Public Health Relevance

There are numerous psychotherapeutic interventions used for individuals with chronic low back pain, yet no treatment is invariably effective for all. Understanding patient characteristics that predict differential responses to these non-pharmacological interventions is critical. Such information allows for a tailored treatment plan that maximizes positive patient impact.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Program--Cooperative Agreements (U19)
Project #
3U19AR076734-01S1
Application #
10202826
Study Section
Program Officer
Marquitz, Aron
Project Start
2019-09-26
Project End
2024-05-31
Budget Start
2020-09-23
Budget End
2024-05-31
Support Year
1
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109