Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program--Cooperative Agreements (U19)
Project #
7U19DK057958-09
Application #
7842992
Study Section
Special Emphasis Panel (ZDK1-GRB-7 (O2))
Program Officer
Appel, Michael C
Project Start
1999-09-30
Project End
2011-07-31
Budget Start
2008-08-01
Budget End
2011-07-31
Support Year
9
Fiscal Year
2006
Total Cost
$1,510,347
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Surgery
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Graham, Melanie L; Rieke, Eric F; Mutch, Lucas A et al. (2012) Successful implementation of cooperative handling eliminates the need for restraint in a complex non-human primate disease model. J Med Primatol 41:89-106
Abouaish, Janine; Graham, Melanie; Bansal-Pakala, Pratima et al. (2011) Successful isolation and transplantation of nonhuman primate islets using a novel purified enzyme blend. Transplantation 92:e40-2
Gansuvd, Balgansuren; Goodwin, Jeanine; Asiedu, Clement K et al. (2008) Invariant natural killer T cells from rhesus macaque spleen and peripheral blood are phenotypically and functionally distinct populations. J Med Primatol 37:1-11
Johnson, J; Pahuja, A; Graham, M et al. (2008) Effects of histone deacetylase inhibitor SAHA on effector and FOXP3+regulatory T cells in rhesus macaques. Transplant Proc 40:459-61
Andrades, P; Asiedu, C K; Gansuvd, B et al. (2008) Pancreatic islet isolation variables in non-human primates (rhesus macaques). Diabetologia 51:1236-44
Asiedu, C; Guarcello, V; Deckard, L et al. (2007) Cloning and characterization of recombinant rhesus macaque IL-10/Fc(ala-ala) fusion protein: a potential adjunct for tolerance induction strategies. Cytokine 40:183-92
Gansuvd, Balgansuren; Asiedu, Clement K; Goodwin, Jeanine et al. (2007) Expansion of CD4+CD25+ suppressive regulatory T cells from rhesus macaque peripheral blood by FN18/antihuman CD28-coated Dynal beads. Hum Immunol 68:478-90
Kim, Geun-Bae; Wang, Zhirui; Liu, Yuan Yi et al. (2007) A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin. Protein Eng Des Sel 20:425-32
Liu, Yuan Yi; Wang, Zhirui; Thomas, Judith et al. (2007) Polymorphisms of CD3epsilon in cynomolgus and rhesus monkeys and their relevance to anti-CD3 antibodies and immunotoxins. Immunol Cell Biol 85:357-62
Asiedu, Clement K; Goodwin, Karen J; Balgansuren, Gansuvd et al. (2005) Elevated T regulatory cells in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin. J Immunol 175:8060-8

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