Abstract

In the next 5 years of the NURSA project, we will carry out a series of advanced data acquisitions that will provide a proteomic atlas for the """"""""systems biology"""""""" of signal-regulated NR pathways in vivo. Such highthroughput data acquisition projects are not themselves possible as R01 mechanisms, yet the accumulated data will greatly stimulate hypothesis-driven research in the entire field of nuclear receptor science. We will pursue the isolation and identification of coregulator (CoR) complexes in mouse tissues, improving protocols For generating protein extracts from mouse tissues of liver, adipocytes, uterus and brain for proteomic analyses, and isolating and identify coregulator protein complexes from mouse tissues for analysis by mass spec. We will carry out profiling of post-translational modifications (PTM) of coregulator complexes and we will also profile coordinated PTMs of NR and CoRs following physiologic signaling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19DK062434-09
Application #
8111778
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
9
Fiscal Year
2010
Total Cost
$295,000
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Kim, Kang Ho; Choi, Sungwoo; Zhou, Ying et al. (2017) Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice. Hepatology 66:498-509
Fleet, Tiffany; Stashi, Erin; Zhu, Bokai et al. (2016) Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology. J Biol Rhythms 31:443-60
Wagner, Martin; Choi, Sungwoo; Panzitt, Katrin et al. (2016) Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology 63:95-106
Han, Sang Jun; Begum, Khurshida; Foulds, Charles E et al. (2016) The Dual Estrogen Receptor ? Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol 89:14-26
Mansuy-Aubert, Virginie; Gautron, Laurent; Lee, Syann et al. (2015) Loss of the liver X receptor LXR?/? in peripheral sensory neurons modifies energy expenditure. Elife 4:
Zhu, Bokai; Gates, Leah A; Stashi, Erin et al. (2015) Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading. Mol Cell 60:769-783
Tseng, Hsiu-Ting; Park, Young Joo; Lee, Yoon Kwang et al. (2015) The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. J Biomed Sci 22:30
Han, Sang Jun; Jung, Sung Yun; Wu, San-Pin et al. (2015) Estrogen Receptor ? Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell 163:960-74
Wu, San-Pin; Kao, Chung-Yang; Wang, Leiming et al. (2015) Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure. Nat Commun 6:8245
Tang, Ke; Tsai, Sophia Y; Tsai, Ming-Jer (2015) COUP-TFs and eye development. Biochim Biophys Acta 1849:201-9

Showing the most recent 10 out of 214 publications