This research program has two overall goals. The first study will identify early characteristics of children with autism and their environments that predict their developmental course. Specifically, the investigators will compare the differential effectiveness of experimental interventions in three domains of non-verbal communication: 1) sharing attention or interests, 2) requesting objects or assistance, and 3) sharing emotions. The second study continues the longitudinal follow-up of a sample of 48 young adults with autism. This study has a twofold objective. First, the investigators will determine whether the transition to adulthood affects symptoms, behavior problems, adaptive behaviors, as well as language and mental skills. Secondly, the study is to identify correlates and predictors of the perceived quality of life of adults with autism and their parents as well as the families? capacities to sustain meaningful routines.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZHD1)
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University of California Los Angeles
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Wegiel, Jerzy; Flory, Michael; Schanen, N Carolyn et al. (2015) Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications. Acta Neuropathol Commun 3:63
Freeman, Stephanny F N; Gulsrud, Amanda; Kasari, Connie (2015) Brief Report: Linking Early Joint Attention and Play Abilities to Later Reports of Friendships for Children with ASD. J Autism Dev Disord 45:2259-66
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Wang, Nicholas J; Parokonny, Alexander S; Thatcher, Karen N et al. (2008) Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15. BMC Genet 9:2
Bookheimer, Susan Y; Wang, A Ting; Scott, Ashley et al. (2008) Frontal contributions to face processing differences in autism: evidence from fMRI of inverted face processing. J Int Neuropsychol Soc 14:922-32

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