Abstract

Biological sample collection, processing, storage, and distribution are essential components of large collaborative genetic studies. The overall objective of the BioRepository Core is to maintain a readily accessible biological specimens bank in support of the projects within this application. The Core services will be provided by the lab facilities located within the Multiple Sclerosis Genetics Program at the Department of Neurology, UCSF. With over two decades of experience, the MS Bio-Bank has both the expertise and infrastructure to serve as an efficient and reliable component of the INDIGO program. In addition to centralizing the management of DNA specimens arriving from different laboratories, the main goal of the Core is to provide standardized samples to the genotyping effort proposed in this application. The Core is well equipped and staffed by experienced personnel. Established standard operating procedures and efficient bioinformatic support will serve the programmatic needs of the INDIGO consortium and secure a valuable resource for future basic and translational research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19NS095774-03
Application #
9335470
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118

  Publications

Misra, Maneesh K; Damotte, Vincent; Hollenbach, Jill A (2018) The immunogenetics of neurological disease. Immunology 153:399-414
Amorim, Leonardo M; Santos, Tiago H S; Hollenbach, Jill A et al. (2018) Cost-effective and fast KIR gene-content genotyping by multiplex melting curve analysis. HLA 92:384-391
Misra, Maneesh K; Damotte, Vincent; Hollenbach, Jill A (2018) Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. Genes Immun :
Wagner, Ines; Schefzyk, Daniel; Pruschke, Jens et al. (2018) Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations. Front Immunol 9:2843
Nemat-Gorgani, Neda; Hilton, Hugo G; Henn, Brenna M et al. (2018) Different Selected Mechanisms Attenuated the Inhibitory Interaction of KIR2DL1 with C2+ HLA-C in Two Indigenous Human Populations in Southern Africa. J Immunol 200:2640-2655
Creary, Lisa E; Mallempati, Kalyan C; Gangavarapu, Sridevi et al. (2018) Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis. Mult Scler :1352458518770019
Misra, Maneesh K; Augusto, Danillo G; Martin, Gonzalo Montero et al. (2018) Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop. Hum Immunol 79:825-833
Isobe, Noriko; Keshavan, Anisha; Gourraud, Pierre-Antoine et al. (2016) Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. JAMA Neurol 73:795-802
Norman, Paul J; Hollenbach, Jill A; Nemat-Gorgani, Neda et al. (2016) Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing. Am J Hum Genet 99:375-91
Hollenbach, J A; Pando, M J; Caillier, S J et al. (2016) The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans. Genes Immun 17:199-202

Showing the most recent 10 out of 11 publications