) We propose a Texas Cancer Genetics Consortium (TCGC) in response to the Cancer Genetics Network (CGN) RFA CA-97-004. This TCGC would bring to the CGN extensive expertise in basic and clinical cancer genetics, human and molecular genetics, management of confidential human cancer genetics data, community outreach in human genetics, professional and public education, and psychosocial studies of the impact of cancer genetic counseling and testing. The TCGC will include existing cancer high risk clinical populations, Ashkenazi Jewish populations, registries of familial breast, colon, MEN2, NF1 and other genetic susceptibility syndromes, many followed in studies for decades, patients at high cancer risk participating in screening and early detection studies or chemoprevention trials, and a large database of cancer patients from which to identify high risk family members for potential recruitment to the CGN. The Texas population is diverse in ethnic makeup, and the TCGC includes investigators with proven track records in assessing needs of the Hispanic and African American communities in health care, in providing health education to those communities and their healthcare providers, and in recruiting their participation in familial cancer registries and clinical and research studies. Funding of this application would provide the opportunity for our TCGC to strengthen our within consortium interactions, to contribute our research experience and expertise to the CGN design and implementation, and to utilize our experience and expertise in recruitment of high risk patients to CGN protocols. The long term goal is to contribute to the identification of cancer susceptibility genes, their mechanisms of action, frequency, penetrance, and genetic or environmental risk modifiers, to integrate this information into optimal patient management, and to assess needs and provide education to address the ethical and psychosocial concerns surrounding human cancer genetics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24CA078142-03
Application #
6173683
Study Section
Special Emphasis Panel (ZCA1-RLB-Y (J2))
Program Officer
Nayfield, Susan G
Project Start
1998-09-01
Project End
2003-06-30
Budget Start
2000-07-20
Budget End
2001-06-30
Support Year
3
Fiscal Year
2000
Total Cost
$1,041,093
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Pediatrics
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Ross, Jessica; Bojadzieva, Jasmina; Peterson, Susan et al. (2017) The psychosocial effects of the Li-Fraumeni Education and Early Detection (LEAD) program on individuals with Li-Fraumeni syndrome. Genet Med 19:1064-1070
Skates, Steven J; Greene, Mark H; Buys, Saundra S et al. (2017) Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials. Clin Cancer Res 23:3628-3637
Hill, Deirdre A; Horick, Nora K; Isaacs, Claudine et al. (2014) Long-term risk of medical conditions associated with breast cancer treatment. Breast Cancer Res Treat 145:233-43
Wang, Ping-Yuan; Ma, Wenzhe; Park, Joon-Young et al. (2013) Increased oxidative metabolism in the Li-Fraumeni syndrome. N Engl J Med 368:1027-32
Ziogas, Argyrios; Horick, Nora K; Kinney, Anita Y et al. (2011) Clinically relevant changes in family history of cancer over time. JAMA 306:172-8
Neklason, Deborah W; Done, Michelle W; Sargent, Nykole R et al. (2011) Activating mutation in MET oncogene in familial colorectal cancer. BMC Cancer 11:424
Skates, Steven J; Mai, Phuong; Horick, Nora K et al. (2011) Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status. Cancer Prev Res (Phila) 4:1401-8
Neklason, Deborah W; Kerber, Richard A; Nilson, David B et al. (2008) Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Res 68:8993-7
Patterson, Annette R; Davis, Helen; Shelby, Kristin et al. (2008) Successful strategies for increasing African American participation in cancer genetic studies: hopeful signs for equalizing the benefits of genetic medicine. Community Genet 11:208-14
Kerber, Richard A; Amos, Christopher I; Yeap, Beow Y et al. (2008) Design considerations in a sib-pair study of linkage for susceptibility loci in cancer. BMC Med Genet 9:64

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