) The Northwest Cancer Genetics Network (NWCGN) - proposed in response to the Cancer Genetics Network (RFA #97004) - will be a resource for studies of the genetic basis of cancer susceptibility, the appropriate use of this information in medical practice, and the impact of knowledge of cancer genetics on public health. To accomplish these aims, we will 1) participate in the development and management of the CGN and 2) will contribute to the CGN a register of individuals interested in cancer screening and/or at defined levels of risk for cancer. The primary focus will be on individuals interested in genetic testing identified from the area genetic clinics (including an existing network in which we participate), via physicians and as self-referrals. In order to ensure representative and efficient recruitment of high-risk individuals, a population-based registry will be established for probands with diagnoses of specific cancers, their family members, and a population sample. All participants will complete a structured interview on family history of cancer, medical history, and other factors thought to influence cancer risk. All participants will be provided individualized risk information. The NWCGN brings to the CGN significant expertise in clinical genetics, molecular genetics, molecular biology, epidemiology, biostatistics, economics, ethics, counseling, primary care and psychology. This mix of disciplines is essential to support the infrastructure required to collect crucial data on individuals seeking genetic testing, as well as those with known family histories.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24CA078164-04
Application #
6376782
Study Section
Special Emphasis Panel (ZCA1-RLB-Y (J2))
Project Start
1998-09-03
Project End
2003-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
4
Fiscal Year
2001
Total Cost
$1,072,178
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Skates, Steven J; Greene, Mark H; Buys, Saundra S et al. (2017) Early Detection of Ovarian Cancer using the Risk of Ovarian Cancer Algorithm with Frequent CA125 Testing in Women at Increased Familial Risk - Combined Results from Two Screening Trials. Clin Cancer Res 23:3628-3637
Lowery, Jan T; Horick, Nora; Kinney, Anita Y et al. (2014) A randomized trial to increase colonoscopy screening in members of high-risk families in the colorectal cancer family registry and cancer genetics network. Cancer Epidemiol Biomarkers Prev 23:601-10
Hill, Deirdre A; Horick, Nora K; Isaacs, Claudine et al. (2014) Long-term risk of medical conditions associated with breast cancer treatment. Breast Cancer Res Treat 145:233-43
Bowen, Deborah J; Hay, Jennifer L; Mayer, Joni et al. (2012) Predictors of recruited melanoma families into a behavioral intervention project. Contemp Clin Trials 33:85-92
Hall, Taryn O; Renz, Anne D; Snapinn, Katherine W et al. (2012) Awareness and uptake of direct-to-consumer genetic testing among cancer cases, their relatives, and controls: the Northwest Cancer Genetics Network. Genet Test Mol Biomarkers 16:744-8
Ziogas, Argyrios; Horick, Nora K; Kinney, Anita Y et al. (2011) Clinically relevant changes in family history of cancer over time. JAMA 306:172-8
Skates, Steven J; Mai, Phuong; Horick, Nora K et al. (2011) Large prospective study of ovarian cancer screening in high-risk women: CA125 cut-point defined by menopausal status. Cancer Prev Res (Phila) 4:1401-8
McBride, Colleen M; Bowen, Deborah; Brody, Lawrence C et al. (2010) Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med 38:556-65
Shah, Chirag A; Lowe, Kimberly A; Paley, Pamela et al. (2009) Influence of ovarian cancer risk status on the diagnostic performance of the serum biomarkers mesothelin, HE4, and CA125. Cancer Epidemiol Biomarkers Prev 18:1365-72
Henrikson, Nora Beidler; Harris, Julie N; Bowen, Deborah J (2007) Predictors of self-referral into a cancer genetics registry. Cancer Epidemiol Biomarkers Prev 16:1387-92

Showing the most recent 10 out of 15 publications