UCLA has a mature small animal imaging program based on micro-positron emission tomography, x-ray micro computed tomography, in-vivo bioluminescence and digital whole body autoradiography imaging. Central to this program, is our small animal imaging resource (SAIR), which provides service and support through a state of the art facility to more than 24 independent Principal Investigators funded through the NIH and other agencies. Most of the research projects of these investigators are focused in cancer diagnosis and therapy. In addition to this service component, the roles of the SAIR within the UCLA and the US environments are to: (a) educate students, post-doctoral scholars, physicians and other biology researchers from within and outside UCLA in the tools, technologies and applications of imaging, and (b) foster collaborations and develop new technologies and methodologies that will improve the quantitative capabilities of non-invasive imaging. These goals will hopefully lead to better understanding of human disease and might lead to better methods for diagnosis and treatment of cancer. As part of this SAIR proposal, besides the research support and education, two developmental projects are included, that should improve the quality and quantitative accuracy of the acquired data, while they reduce the impact from radiation exposure on the studied subjects. The first project will seek to standardize the animal handling and care part of the imaging protocol prior to, during and after the procedure, such that the animal's response is as uniform as possible. The second project seeks to estimate at first, secondly optimize and thirdly track the radiation exposure to the animal subjects throughout sequences of multiple imaging experiments that can last several months. Both these projects will greatly benefit not only the research experiments carried through the UCLA SAIR, but all preclinical research in the US. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
2U24CA092865-07
Application #
7235085
Study Section
Special Emphasis Panel (ZCA1-GRB-S (J1))
Program Officer
Croft, Barbara
Project Start
2001-07-01
Project End
2012-01-31
Budget Start
2007-02-19
Budget End
2008-01-31
Support Year
7
Fiscal Year
2007
Total Cost
$444,188
Indirect Cost
Name
University of California Los Angeles
Department
Pharmacology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Chang, Yen-Chi; Berry-Pusey, Brittany; Yasin, Rashid et al. (2015) An Automated Mouse Tail Vascular Access System by Vision and Pressure Feedback. IEEE ASME Trans Mechatron 20:1616-1623
Wang, Hongkai; Stout, David B; Chatziioannou, Arion F (2015) A deformable atlas of the laboratory mouse. Mol Imaging Biol 17:18-28
Gu, Z; Prout, D L; Silverman, R W et al. (2015) A DOI Detector With Crystal Scatter Identification Capability for High Sensitivity and High Spatial Resolution PET Imaging. IEEE Trans Nucl Sci 62:740-747
Fu, Maoyong; Brewer, Sarah; Olafsen, Tove et al. (2013) Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. Mol Imaging Biol 15:68-78
Cai, Wen; Chen, Qi; Cherepy, Nerine et al. (2013) Synthesis of bulk-size transparent gadolinium oxide-polymer nanocomposites for gamma ray spectroscopy. J Mater Chem C Mater 1:1970-1976
Berry-Pusey, B N; Chang, Y C; Prince, S W et al. (2013) A semi-automated vascular access system for preclinical models. Phys Med Biol 58:5351-62
Gu, Z; Taschereau, R; Vu, N T et al. (2013) NEMA NU-4 performance evaluation of PETbox4, a high sensitivity dedicated PET preclinical tomograph. Phys Med Biol 58:3791-814
Wang, Hongkai; Stout, David B; Chatziioannou, Arion F (2013) A method of 2D/3D registration of a statistical mouse atlas with a planar X-ray projection and an optical photo. Med Image Anal 17:401-16
Wang, Hongkai; Stout, David B; Chatziioannou, Arion F (2012) Mouse atlas registration with non-tomographic imaging modalities-a pilot study based on simulation. Mol Imaging Biol 14:408-19
McCabe, Katelyn E; Liu, Bin; Marks, James D et al. (2012) An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors. Mol Imaging Biol 14:336-47

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