We propose to establish the Southwestern Small Animal Imaging Resource (SW-SAIR). This represents a formal structure to promote and facilitate small animal imaging research related to cancer at UT Southwestern. It will use facilities, expertise, and resources of the Department of Radiology, Simmons Comprehensive Cancer Center, and the new Advanced Imaging Research Center. Major recent investment in imaging has provided a new building and substantial infrastructure (instruments, space, and personnel) based on a tripod of collaboration between UT Southwestern Medical Center, UT Dallas and UT Arlington. Based on a Pre-ICMIC, there has been major developing interest in small animal imaging at UT Southwestern. Numerous new grants incorporating or focused on imaging (over $2M), 24 peer-reviewed publications, and multiple new trainees and multiple new collaborations have come to fruition in the past two years alone. We will initially offer research advice and service in bioluminescent imaging, including our unique multi-head light emission tomography system, MRI and PET based on current instrumentation. To facilitate effective research, we will also have a Reporter Molecule Core to facilitate routine and novel radio labeling and cold chemistry for the development of ligands as reporter molecules. We will also provide support in data analysis and archiving. Our Dean has committed to purchase additional instruments providing SPECT/CT and upgrading the small animal PET and MRI. The SW-SAIR will have three primary functions i) provide state of the art small animal imaging infrastructure to support a total of 12 Base Grants. These represent Federally funded cancer research including SPORE, PPG and R01 grants with disease sites including lung, brain, prostate, breast and bladder. The grants represent concepts ranging from drug development to tumor physiology to reporter molecule development, ii) research and development to push the frontiers of small animal imaging related to three dimensional bioluminescence and novel molecular targeting agents using the PARACEST approach, and iii) training through an annual symposium, regular seminars and hands-on instruction. The opening of a new 150, 000 sq ft Advanced Imaging Research Center provides the SW-SAIR access to new state of the art small animal MR, PET, and SPECT/CT facilities as well as space for recruitment of new imaging researchers. The SW-SAIR will not only provide an important regional resource, but will also represent leadership in imaging innovation at the national and international levels.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-S (J1))
Program Officer
Zhang, Huiming
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Sw Medical Center Dallas
Schools of Medicine
United States
Zip Code
Luo, Min; Wang, Hua; Wang, Zhaohui et al. (2017) A STING-activating nanovaccine for cancer immunotherapy. Nat Nanotechnol 12:648-654
Wen, Xiaodong; Reynolds, Lacy; Mulik, Rohit S et al. (2016) Hepatic Arterial Infusion of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles Selectively Disrupts Redox Balance in Hepatoma Cells and Reduces Growth of Orthotopic Liver Tumors in Rats. Gastroenterology 150:488-98
Mulik, Rohit S; Bing, Chenchen; Ladouceur-Wodzak, Michelle et al. (2016) Localized delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat brain using focused ultrasound. Biomaterials 83:257-68
Hallac, Rami R; Zhou, Heling; Pidikiti, Rajesh et al. (2016) A role for dynamic contrast-enhanced magnetic resonance imaging in predicting tumour radiation response. Br J Cancer 114:1206-11
Zhang, Liang; Zhang, Zhongwei; Mason, Ralph P et al. (2015) Convertible MRI contrast: Sensing the delivery and release of anti-glioma nano-drugs. Sci Rep 5:9874
Wang, Xiaojing; Wu, Yunkou; Soesbe, Todd C et al. (2015) A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window. Angew Chem Int Ed Engl 54:8662-4
Slavine, Nikolai V; McColl, Roderick W (2015) Semi-automated Image Processing for Preclinical Bioluminescent Imaging. J Appl Bioinforma Comput Biol 4:
Zhao, Dawen; Pacheco-Torres, Jesús; Hallac, Rami R et al. (2015) Dynamic oxygen challenge evaluated by NMR T1 and T2*--insights into tumor oxygenation. NMR Biomed 28:937-947
Liu, Li; Mason, Ralph P; Gimi, Barjor (2015) Dynamic bioluminescence and fluorescence imaging of the effects of the antivascular agent Combretastatin-A4P (CA4P) on brain tumor xenografts. Cancer Lett 356:462-9
Singh, Ajay N; McGuire, Michael J; Li, Shunzi et al. (2014) Dimerization of a phage-display selected peptide for imaging of ?v?6- integrin: two approaches to the multivalent effect. Theranostics 4:745-60

Showing the most recent 10 out of 126 publications