This application is for a competitive renewal and transformation of the HMO Cancer Research Network (CRN) into a research resource. The CRN, which has been continuously funded since 1999, provides infrastructure support to conduct cancer research in the setting of not-for-profit integrated health care delivery systems. The setting has advantages for conducting population sciences research that collectively result in a unique, unparalleled resource for conducting epidemiologic and health services research in cancer. These advantages include externally-funded research groups with investigators with expertise in conducting public-domain cancer research in these settings;defined populations with a combined membership of over 10 million individuals for whom health care is provided;clinical and administrative data systems that capture most aspects of care;development and implementation of common data models in the Virtual Data Warehouse (VDW) to facilitate collaborative and multi-institutional research;and access to clinicians and administrators to facilitate translation of research findings to practice. We plan to enhance the CRN in several areas, including: Establishing an Informatics Core focused on continual improvement of the VDW through implementation of distributed query tools to facilitate preparatory-to-research and collaborative research studies, and improvement of existing and implementation of new VDW domains of relevance to cancer research;identification and promotion of research in strategic areas for which the CRN is uniquely positioned (i.e., Prevention &Screening;Treatment &Outcomes;Biospecimens &Molecular Applications;Communications &Decision-Making;Health Care Quality &Cost;and Dissemination &Implementation);institutionalizing a CRN Scholars mentored career development program for junior investigators;continuation of a Developmental and Pilot Studies Program to support pilot studies and to enhance infrastructure;and implementation of an Outreach and External Collaborations Core to facilitate research collaborations. This continued infrastructure support will enable and facilitate researchers'continued access to large integrated delivery systems and motivate continued evolution as the nation's premier learning healthcare systems.

Public Health Relevance

This application for the Cancer Research Network supports activities that enhance the ability to conduct impactful, relevant cancer research in integrated health care systems that provide health care to over 10 million members. Activities include data resource enhancement, career development of junior investigators, funding of promising pilot studies, and promotion of collaborations among research scientists.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24CA171524-03
Application #
8733630
Study Section
Special Emphasis Panel (ZCA1-SRLB-B (M2))
Program Officer
Grauman, Alyssa
Project Start
2012-09-25
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
$3,087,748
Indirect Cost
$303,065
Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
150829349
City
Oakland
State
CA
Country
United States
Zip Code
94612
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Pannucci, TusaRebecca E; Thompson, Frances E; Bailey, Regan L et al. (2018) Comparing Reported Dietary Supplement Intakes between Two 24-Hour Recall Methods: The Automated Self-Administered 24-Hour Dietary Assessment Tool and the Interview-Administered Automated Multiple Pass Method. J Acad Nutr Diet 118:1080-1086
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Banegas, Matthew P; Emerson, Marc A; Adams, Alyce S et al. (2018) Patterns of medication adherence in a multi-ethnic cohort of prevalent statin users diagnosed with breast, prostate, or colorectal cancer. J Cancer Surviv 12:794-802
Bandera, Elisa V; Lee, Valerie S; Qin, Bo et al. (2017) Impact of body mass index on ovarian cancer survival varies by stage. Br J Cancer 117:282-289
Menter, Alex R; Carroll, Nikki M; Sakoda, Lori C et al. (2017) Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer. Clin Lung Cancer 18:189-197.e3
Salloum, Ramzi G; O'Keeffe-Rosetti, Maureen; Ritzwoller, Debra P et al. (2017) Use of Evidence-Based Prostate Cancer Imaging in a Nongovernmental Integrated Health Care System. J Oncol Pract 13:e441-e450
Engmann, Natalie J; Ergas, Isaac J; Yao, Song et al. (2017) Genetic Ancestry Is not Associated with Breast Cancer Recurrence or Survival in U.S. Latina Women Enrolled in the Kaiser Permanente Pathways Study. Cancer Epidemiol Biomarkers Prev 26:1466-1469
Gould, Michael K; Sakoda, Lori C; Ritzwoller, Debra P et al. (2017) Monitoring Lung Cancer Screening Use and Outcomes at Four Cancer Research Network Sites. Ann Am Thorac Soc 14:1827-1835
Yao, Song; Zhang, Yali; Tang, Li et al. (2017) Bone remodeling and regulating biomarkers in women at the time of breast cancer diagnosis. Breast Cancer Res Treat 161:501-513

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