This application is for a competitive renewal and transformation of the HMO Cancer Research Network (CRN) into a research resource. The CRN, which has been continuously funded since 1999, provides infrastructure support to conduct cancer research in the setting of not-for-profit integrated health care delivery systems. The setting has advantages for conducting population sciences research that collectively result in a unique, unparalleled resource for conducting epidemiologic and health services research in cancer. These advantages include externally-funded research groups with investigators with expertise in conducting public-domain cancer research in these settings;defined populations with a combined membership of over 10 million individuals for whom health care is provided;clinical and administrative data systems that capture most aspects of care;development and implementation of common data models in the Virtual Data Warehouse (VDW) to facilitate collaborative and multi-institutional research;and access to clinicians and administrators to facilitate translation of research findings to practice. We plan to enhance the CRN in several areas, including: Establishing an Informatics Core focused on continual improvement of the VDW through implementation of distributed query tools to facilitate preparatory-to-research and collaborative research studies, and improvement of existing and implementation of new VDW domains of relevance to cancer research;identification and promotion of research in strategic areas for which the CRN is uniquely positioned (i.e., Prevention &Screening;Treatment &Outcomes;Biospecimens &Molecular Applications;Communications &Decision-Making;Health Care Quality &Cost;and Dissemination &Implementation);institutionalizing a CRN Scholars mentored career development program for junior investigators;continuation of a Developmental and Pilot Studies Program to support pilot studies and to enhance infrastructure;and implementation of an Outreach and External Collaborations Core to facilitate research collaborations. This continued infrastructure support will enable and facilitate researchers'continued access to large integrated delivery systems and motivate continued evolution as the nation's premier learning healthcare systems.
This application for the Cancer Research Network supports activities that enhance the ability to conduct impactful, relevant cancer research in integrated health care systems that provide health care to over 10 million members. Activities include data resource enhancement, career development of junior investigators, funding of promising pilot studies, and promotion of collaborations among research scientists.
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|Banegas, Matthew P; Emerson, Marc A; Adams, Alyce S et al. (2018) Patterns of medication adherence in a multi-ethnic cohort of prevalent statin users diagnosed with breast, prostate, or colorectal cancer. J Cancer Surviv 12:794-802|
|Yao, Song; Kwan, Marilyn L; Ergas, Isaac J et al. (2017) Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival: A Case-Cohort Analysis in the Pathways Study. JAMA Oncol 3:351-357|
|Singal, Amit G; Tiro, Jasmin; Li, Xilong et al. (2017) Hepatocellular Carcinoma Surveillance Among Patients With Cirrhosis in a Population-based Integrated Health Care Delivery System. J Clin Gastroenterol 51:650-655|
|Lieu, Tracy A; Ray, G Thomas; Prausnitz, Stephanie R et al. (2017) Oncologist and organizational factors associated with variation in breast cancer multigene testing. Breast Cancer Res Treat 163:167-176|
|Hillyer, Grace Clarke; Jensen, Christopher D; Zhao, Wei K et al. (2017) Primary care visit use after positive fecal immunochemical test for colorectal cancer screening. Cancer 123:3744-3753|
|Feigelson, Heather Spencer; McMullen, Carmit K; Madrid, Sarah et al. (2017) Optimizing patient-reported outcome and risk factor reporting from cancer survivors: a randomized trial of four different survey methods among colorectal cancer survivors. J Cancer Surviv 11:393-400|
|Buist, Diana S M; Field, Terry S; Banegas, Matthew P et al. (2017) Training in the Conduct of Population-Based Multi-Site and Multi-Disciplinary Studies: the Cancer Research Network's Scholars Program. J Cancer Educ 32:283-292|
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