In its initial funding period, the ABCD consortium used a rigorous epidemiological approach to recruit a diverse sample of 11,878 9- to 10-year-olds through our 21 research sites, of which 2,136 are twins or triplets. Expert workgroups (WGs) designed protocols using proven methods to assess, scan, and maintain this cohort with very high retention rates. The study complements well validated standardized assessments with novel real-time objective data collected wirelessly in the natural environment to securely capture indices of youth behaviors. These technologies add measurement precision, ecological validity, and an opportunity to reveal previously unknown effects of behavioral, physiological, and environmental factors in the development and fluctuation of substance use, screen media use, mental and physical health concerns, brain development, and their dynamic relationships. Bioassays (e.g., from hair, shed teeth, blood, and oral fluid) provide genome-wide genotyping, pubertal hormones, more precise estimates of exposures to substances of abuse and environmental toxins, and eventually more comprehensive estimates of relevant epigenetic effects. State-of-the-art harmonization methods for MRI and other data enable seamless data integration across sites into an invaluable open-science database that becomes available to the larger scientific community within a year of data collection. The Coordinating Center (CC) met all of its previous aims, and here describes how it will achieve an adjusted set of aims for the next 7 years. Specifically, we describe a flexible organizational framework created for management of the study that relies heavily on cross-disciplinary knowledge and extensive research experience of expert assessment WGs and strategic planning groups, and a dedicated team within the CC, Data Analysis, Informatics and Resource Center (DAIRC), and NIH to coordinate internal and external communications; support and integrate the development and revision of protocols and data quality reviews performed by WGs; establish, monitor, and maintain the standardization of study protocols across the consortium sites; measure and review study progress toward goals for retention, data quality, and scientific impact; based on these metrics, take supportive and corrective action to ensure that the goals are met; manage bioethics policies and consortium interactions with the single IRB (sIRB); promote the professional development of diverse junior investigators; establish a framework to resolve conflicts within the CC or within the wider consortium; and responsibly address any unanticipated scientific, methodological, logistical, or ethical challenges to ensure the study achieves its overarching objectives. We also describe how the CC and DAIRC will together implement quality control procedures to improve data quality across all data types; coordinate data sharing functions with the staff of the NIMH Data Archive; manage a pipeline for enhancing the study with novel assessment technologies; and facilitate rigorous analyses of ABCD data that set new standards for use of data from this powerful, but complex and challenging, high-dimensional study.

Public Health Relevance

The landmark Adolescent Brain Cognitive Development (ABCD) Study is following over 11,800 children beginning at 9 and 10 years of age in 21 U.S. communities. Over the next 7 years, the study aims to provide critical information about what factors present during their adolescent and young adult years may either strengthen their development or place them at higher risk of poor mental, physical, or behavioral health.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Deeds, Bethany
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California, San Diego
Schools of Arts and Sciences
La Jolla
United States
Zip Code
Walsh, Jeremy J; Barnes, Joel D; Cameron, Jameason D et al. (2018) Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study. Lancet Child Adolesc Health 2:783-791
Morris, Amanda Sheffield; Squeglia, Lindsay M; Jacobus, Joanna et al. (2018) Adolescent Brain Development: Implications for Understanding Risk and Resilience Processes Through Neuroimaging Research. J Res Adolesc 28:4-9
Zucker, Robert A; Gonzalez, Raul; Feldstein Ewing, Sarah W et al. (2018) Assessment of culture and environment in the Adolescent Brain and Cognitive Development Study: Rationale, description of measures, and early data. Dev Cogn Neurosci 32:107-120
Casey, B J; Cannonier, Tariq; Conley, May I et al. (2018) The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites. Dev Cogn Neurosci 32:43-54
Barch, Deanna M; Albaugh, Matthew D; Avenevoli, Shelli et al. (2018) Demographic, physical and mental health assessments in the adolescent brain and cognitive development study: Rationale and description. Dev Cogn Neurosci 32:55-66
Lisdahl, Krista M; Sher, Kenneth J; Conway, Kevin P et al. (2018) Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods. Dev Cogn Neurosci 32:80-96
Clark, Duncan B; Fisher, Celia B; Bookheimer, Susan et al. (2018) Biomedical ethics and clinical oversight in multisite observational neuroimaging studies with children and adolescents: The ABCD experience. Dev Cogn Neurosci 32:143-154