The present proposal seeks to transfer the University of Pittsburgh temporal bone collection to Mass Eye and Ear. The University of Pittsburg has entrusted Mass Eye and Ear and the National Temporal Bone Registry to house and preserve the Sando Temporal Bone collection. This collection is one of the largest collections in the world and is of significant scientific value in the study of human hearing and vestibular disorders. It includes 880 trays of stained and a similar amount of unstained sections. There are 265 temporal bones in celloidin with accompanying histories, autopsy reports and audiograms. The case also includes 21 cases of unique coronal sections that include the entire Eustachian tube. We will make this collection accessible to investigators by incorporating the collection into the National Temporal Bone Registry database. Housing the collection at Mass Eye and Ear will also facilitate the digitalization of the histological slides for remote access.

Public Health Relevance

As this is a large collection, transfer to Boston from Pittsburgh requires the service of professional movers. To house the collection, we have already installed new cabinets in our existing space, the cost of which is included in this request along with the cost of the movers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24DC013983-07S1
Application #
10246583
Study Section
Program Officer
Poremba, Amy
Project Start
2014-09-01
Project End
2024-09-30
Budget Start
2020-09-01
Budget End
2021-09-30
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
02114
Okayasu, Tadao; O'Malley, Jennifer T; Nadol Jr, Joseph B (2018) Focal Degeneration of Vestibular Neuroepithelium in the Cristae Ampullares of Three Human Subjects. Otol Neurotol 39:e1100-e1110
Handzel, Ophir; Nadol Jr, Joseph B (2018) Temporal Bone Histopathology in Cockayne Syndrome. Otol Neurotol 39:e387-e391
Trakimas, Danielle R; Kozin, Elliott D; Ghanad, Iman et al. (2018) Human Otopathologic Findings in Cases of Folded Cochlear Implant Electrodes. Otol Neurotol 39:970-978
Kamakura, Takefumi; O'Malley, Jennifer T; Nadol Jr, Joseph B (2018) Preservation of Cells of the Organ of Corti and Innervating Dendritic Processes Following Cochlear Implantation in the Human: An Immunohistochemical Study. Otol Neurotol 39:284-293
Sagers, Jessica E; Landegger, Lukas D; Worthington, Steven et al. (2017) Human Cochlear Histopathology Reflects Clinical Signatures of Primary Neural Degeneration. Sci Rep 7:4884
O'Malley, Jennifer T; Burgess, Barbara J; Galler, Donald et al. (2017) Foreign Body Response to Silicone in Cochlear Implant Electrodes in the Human. Otol Neurotol 38:970-977
Ishai, Reuven; Herrmann, Barbara S; Nadol Jr, Joseph B et al. (2017) The pattern and degree of capsular fibrous sheaths surrounding cochlear electrode arrays. Hear Res 348:44-53
Jung, David H; Nadol Jr, Joseph B; Folkerth, Rebecca D et al. (2016) Histopathology of the Inner Ear in a Case With Recent Onset of Cogan's Syndrome: Evidence for Vasculitis. Ann Otol Rhinol Laryngol 125:20-4
Nadol Jr, Joseph B (2016) Focal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear. Otol Neurotol 37:859-64
Quesnel, Alicia M; Nakajima, Hideko Heidi; Rosowski, John J et al. (2016) Delayed loss of hearing after hearing preservation cochlear implantation: Human temporal bone pathology and implications for etiology. Hear Res 333:225-234

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