In concert with highly qualified Internal and External Advisory committees, the University of Florida College of Dentistry (UFCD) has completed a comprehensive evaluation and Needs Assessment of our research programs. UFCD has identified a core group of basic and patient-oriented researchers upon which to build a broad-based, multidisciplinary research program that is capable of fully integrating basic and clinical oral health sciences with four major initiatives on the University of Florida campus and Health Sciences Center. A Research Infrastructure Enhance Plan has been developed that has the full support of UF and Health Science Center administration and provides a logical and sustainable strategy for creating a research enterprise that is capable of meeting the challenges of the NIDCR Strategic Plan and the NIH Roadmap. To achieve these goals, a single specific aim has been established: To implement a highly focused, realistic and achievable Research Infrastructure Enhancement Plan developed in response to a Needs Assessment by our Internal and External Advisory committees. The Plan has four primary components: a) Establish a Clinical and Translational Research enterprise that will complement existing basic science strengths at UFCD and with key clinical and basic science initiatives at University of Florida. b) Conduct targeted recruitments for two basic scientists to achieve critical mass in the area of Cell and Molecular Biology to underpin the Clinical and Translational program. c) Create a formal Training and Mentoring Structure that will fully support the research mission of the College during the transition through the Research Enhancement phase and will sustain the research enterprise of the College and Health Sciences Center in the long-term. d) Solidify linkages of the UFCD with four areas of excellence at the University of Florida - The Genetics Institute, the Diabetes Research groups, the Cancer Center, and the McKnight Brain Institute - and establish firm ties with the UF General Clinical Research Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DE016509-02
Application #
6951978
Study Section
Special Emphasis Panel (ZDE1-GH (44))
Program Officer
Hardwick, Kevin S
Project Start
2004-09-24
Project End
2008-08-31
Budget Start
2005-09-01
Budget End
2008-08-31
Support Year
2
Fiscal Year
2005
Total Cost
$1,455,000
Indirect Cost
Name
University of Florida
Department
Dentistry
Type
Schools of Dentistry
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Lucas, Alexandra R; Verma, Raj K; Dai, Erbin et al. (2014) Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic Porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice. PLoS One 9:e111353
Koutouzis, Theofilos; Catania, Dominick; Neiva, Kathleen et al. (2013) Innate immune receptor expression in peri-implant tissues of patients with different susceptibility to periodontal diseases. J Periodontol 84:221-9
Das, Biswadip; Cash, Melanie N; Robinson, Bently et al. (2013) The sld genetic defect: two intronic CA repeats promote insertion of the subsequent intron and mRNA decay. J Biol Chem 288:14742-55
Catalfamo, Dana L; Calderon, Nadia L; Harden, Scott W et al. (2013) Augmented LPS responsiveness in type 1 diabetes-derived osteoclasts. J Cell Physiol 228:349-61
Kesavalu, L; Lucas, A R; Verma, R K et al. (2012) Increased atherogenesis during Streptococcus mutans infection in ApoE-null mice. J Dent Res 91:255-60
Bakthavatchalu, V; Meka, A; Mans, J J et al. (2011) Polymicrobial periodontal pathogen transcriptomes in calvarial bone and soft tissue. Mol Oral Microbiol 26:303-20
Nahid, Md A; Rivera, Mercedes; Lucas, Alexandra et al. (2011) Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease. Infect Immun 79:1597-605
Delano, Matthew J; Thayer, Terri; Gabrilovich, Sonia et al. (2011) Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol 186:195-202
Amir, Jamie; Waite, Matthew; Tobler, Jeffrey et al. (2011) The role of hyperglycemia in mechanisms of exacerbated inflammatory responses within the oral cavity. Cell Immunol 272:45-52
Aris, John P; Elios, Megan C; Bimstein, Enrique et al. (2010) Gingival RAGE expression in calorie-restricted versus ad libitum-fed rats. J Periodontol 81:1481-7

Showing the most recent 10 out of 23 publications