Cardiovascular and renal complications, including atherosclerosis and lipid abnormalities, diabeticcardiomyopathy, stroke and renal disease, comprise the major morbidity and mortality in diabetes. Thecomplications of diabetes mellitus in mice appear to be largely the same as in humans. The purpose of theCardiovascular Pathophysiology and Complications Core (CPCC) is to provide rapid, comprehensive, andaccurate screening for cardiovascular disease and complications of diabetes in mouse models. The mousephenotyping tests used by this Core are modeled after and directly translatable to tests used to assesspatients with diabetes. Core services include assessment of a) cardiac morphology and function, includingmorphology, histology and echocardiography; b) vascular regulation, including resting measurement of bloodpressure and response to vasomotor perturbations; c) exercise capacity and metabolic function; d)comprehensive renal function; e) microvascular function; and f) circulating markers of cardiovascular diseaseincluding electrolytes, indices of renal function, glycated hemoglobin, and serum lipids. The range ofphenotyping tests performed by the CPCC allows for thorough investigation of the presence, correlation with,and modification or amelioration of cardiovascular disease, as well as diabetic complications associated withspecific genetic manipulations in the mouse.
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