Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24HL058930-01S1
Application #
2721070
Study Section
Special Emphasis Panel (ZHL1 (M1))
Project Start
1997-09-30
Project End
2001-08-31
Budget Start
1998-01-01
Budget End
1998-08-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kiryu, Shigeru; Sundaram, Tessa; Kubo, Shigeto et al. (2008) MRI assessment of lung parenchymal motion in normal mice and transgenic mice with sickle cell disease. J Magn Reson Imaging 27:49-56
Uematsu, Hidemasa; Takahashi, Masaya; Hatabu, Hiroto et al. (2007) Changes in T1 and T2 observed in brain magnetic resonance imaging with delivery of high concentrations of oxygen. J Comput Assist Tomogr 31:662-5
Obata, Kazuo; Mattiello, Julian; Asakura, Kenji et al. (2006) Exposure of blood from patients with sickle cell disease to air changes the morphological, oxygen-binding, and sickling properties of sickled erythrocytes. Am J Hematol 81:26-35
Abdulmalik, Osheiza; Safo, Martin K; Chen, Qiukan et al. (2005) 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol 128:552-61
Asakura, Toshio; Asakura, Kenji; Obata, Kazuo et al. (2005) Blood samples collected under venous oxygen pressure from patients with sickle cell disease contain a significant number of a new type of reversibly sickled cells: constancy of the percentage of sickled cells in individual patients during steady state. Am J Hematol 80:249-56
Zhang, Chaojie; Li, Xiang; Lian, Lurong et al. (2004) Anti-sickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents. Br J Haematol 125:788-95
Iyamu, Efemwonkiekie W; Adunyah, Samuel E; Fasold, Hugo et al. (2003) Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line. Exp Hematol 31:592-600
Iyamu, Efemwonkiekie W; Turner, Ernest A; Asakura, Toshio (2003) Niprisan (Nix-0699) improves the survival rates of transgenic sickle cell mice under acute severe hypoxic conditions. Br J Haematol 122:1001-8
Iyamu, Efemwonkiekie W; Turner, Ernest A; Asakura, Toshio (2002) In vitro effects of NIPRISAN (Nix-0699): a naturally occurring, potent antisickling agent. Br J Haematol 118:337-43
Iyamu, W E; Lian, L; Asakura, T (2001) Pharmacokinetic profile of the anti-sickling hydroxyurea in wild-type and transgenic sickle cell mice. Chemotherapy 47:270-8

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