We propose a comprehensive approach to the NINDS Human Biomarkers Biospecimen and Data Repository that will fulfill all requirements listed in RFA-NS-15-010. Indiana University currently houses key repositories in the areas of Alzheimer's disease, Parkinson's disease and concussion research. We have developed a strong administrative structure that ensures that all aspects of biorepository function are well designed and maintained. All processes are driven by standard operating procedures, ensuring uniformity at all levels. We will build on our successful biorepository experience to create a strong partnership with all groups funded by NINDS as well as partner organizations. This will ensure that a comprehensive approach to biobanking is developed for the NINDS Biomarker Repository that will allow samples to meet the needs of future research. The success of this effort will be maximized by our ability to coordinate the needs of multiple related biorepositories housed here at Indiana University. Based on our past success in establishing widely used biospecimen repositories, we propose under the oversight of NINDS and the Scientific Liaison Committee, the following specific aims:
Aim 1 : Establish a strong administrative structure that will oversee all aspects of the NINDS Biomarker Repository.
Aim 2 : Create and maintain a state-of-the-art biospecimen repository that receives processes and stores all samples from approved studies.
Aim 3 : Coordinate all data management and web-based activities of the NINDS Biomarker Biorepository.

Public Health Relevance

This application proposes to establish at Indiana University a comprehensive biomarker repository for Parkinson's disease, Huntington's Disease and traumatic brain injury. We will work closely with NINDS, the investigators banking samples, as well as researchers requesting samples to ensure that the biospecimens we bank and distribute are of the highest quality. These samples will be used to perform research with the ultimate goal of developing new treatments for these disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24NS095871-05
Application #
9783889
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Miller, Daniel L
Project Start
2015-09-30
Project End
2020-09-29
Budget Start
2019-09-30
Budget End
2020-09-29
Support Year
5
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Genetics
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Gwinn, Katrina; David, Karen K; Swanson-Fischer, Christine et al. (2017) Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program. Biomark Med 11:451-473