The last decade has seen significant advances in stroke prevention, treatment, rehabilitation, and recovery. Yet, more externally valid effectiveness trials with diverse populations are critical. Current stroke trials are challenged by inefficiencies, such as multiple institutional review boards, trial agreements, and trial networks, which can lead to slow or incomplete enrollment, variable quality, and high costs. The NIH Stroke Trials Network (StrokeNet) was founded with the purpose of addressing these issues. The use of a central IRB, Master Trial Agreement and use of a single electronic data capture system (webDCU) were implemented with to reduce start-up times and improve data quality. Inclusion of centers across the US aims to increase participant numbers and diversity. University of Utah Health (UUH) is a highly successful NIH StrokeNet Regional Coordinating Center (RCC). Utah (UT) StrokeNet is centered in the Mountain West, a 5-state region covering 10% of the U.S. landmass with 12.8 million inhabitants of increasing diversity. UT StrokeNet includes 9 Clinical Performing Sites (CPS), 8 adult and 1 pediatric, in Utah, Colorado, and Arizona. In the next funding period, UT StrokeNet will continue to efficiently implement and successfully conduct multiple adult and pediatric StrokeNet trials using the combined strength of all 9 sites. UT StrokeNet aims to provide access to high quality, innovative trials to all Mountain West stroke patients, regardless of patient sex or location. UT StrokeNet will focus on further increasing minority recruitment by providing cultural competency training to its study teams as well as maximizing access to clinical trials for patients living in rural and frontier areas through the use of the Telestroke Network. The local leadership team will continue to serve on national network committees to contribute to StrokeNet operations. UT StrokeNet will also facilitate multi-disciplinary collaborations of local clinical and translational stroke experts (with a strong focus on stroke rehabilitation) in order to propose innovative trials to NINDS and the Network. UT StrokeNet will foster the education and career development of post-doctoral clinical and translational scientists through a focused, individualized training program that includes experiential learning, optional coursework, and career and research mentoring. By achieving these goals, UT StrokeNet will contribute to the continued development of the national stroke trials network, advancement of stroke research, and, ultimately, an improvement of stroke care for all persons in the Mountain West.

Public Health Relevance

Stroke is the 5th leading cause of mortality in the US and the leading cause of adult disability and thus constitutes a major public health burden. Utah StrokeNet is one of 25 Regional Coordinating Centers that form the national NIH-sponsored Stroke Trials Network (StrokeNet). Utah StrokeNet aims to assist in development, promotion, and provision of the highest quality clinical stroke trials in stroke prevention, treatment, and recovery to patients across the Mountain West, whether urban, rural, or frontier.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24NS107228-02
Application #
9756484
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Vivalda, Joanna
Project Start
2018-08-15
Project End
2023-07-31
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Utah
Department
Neurology
Type
Schools of Medicine
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112