South Africa is one of the five countries worldwide that rank in the top ten of highest TB burden, highest TB/HIV burden and highest HIV burden. The lack of experienced investigators in clinical, operational and health services research s one of the main reasons behind the failure of South Africa to meet its tuberculosis control targets. This is a combined application from two prior planning grants from three South African universities (University of the Witwatersrand, University of Cape Town, Stellenbosch University) and two US universities (Johns Hopkins and University of North Carolina at Chapel Hill) to create a comprehensive TB training program. We shall teach short term courses in HIV, TB, research methods and research ethics in South Africa, identify talented South Africans for intermediate and long term training in South Africa and the US, mentor them throughout their training, fund them for preliminary research after completion of training and help them establish independent careers in South African. We have also established a link with the University of Malawi ICOHRTA to provide South to South training opportunities and the three other Fogarty grants: Douglas Wassnaar-bioethics training at University of Pretoria; Mike Merson and Mary Crewe-HIV prevention training at University of Pretoria and Yale; Slim Karim at University of KwaZulu-Natal and Columbia.
Specific aims : 1 Train a cadre of senior faculty through 21 student years of MPH/PhD and 28 intermediate term experiences to carry out operations, health services and clinical research studying TB/HIV questions relevant to South Africa. 2.Train a cadre of junior faculty and staff, government and NGO staff through short term experiences in grants management, Good Clinical Practice, Human subjects protections, basic epidemiology and TB and HIV S.Train a team of at least 4 leaders from government, academia and NGOs to work in a cohesive manner through leadership training in the Public Health Leadership program at UNC 4.Create a sustainable TB training program in South Africa which does not require US investigator input 5.Strengthen the linkages of HIV/TB investigators throughout South Africa at University of the Witwatersrand, University of Cape Town, University of Pretoria, Stellenbosch University and University of KwaZulu-Natal through annual meetings focused on TB/HIV. ? ? ?

National Institute of Health (NIH)
Fogarty International Center (FIC)
International Research Training Cooperative Agreements (U2R)
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Special Emphasis Panel (ZRG1-ICP2-B (51))
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Mcdermott, Jeanne
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Wits Health Consortium (Pty), Ltd
South Africa
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du Preez, Karen; Schaaf, H Simon; Dunbar, Rory et al. (2018) Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children. BMC Public Health 18:397
Sinxadi, Phumla Zuleika; McIlleron, Helen Margaret; Dave, Joel Alex et al. (2016) Plasma Efavirenz Concentrations Are Associated With Lipid and Glucose Concentrations. Medicine (Baltimore) 95:e2385
Maskew, Mhairi; Fox, Matthew P; Evans, Denise et al. (2016) Insights into Adherence among a Cohort of Adolescents Aged 12-20 Years in South Africa: Reported Barriers to Antiretroviral Treatment. AIDS Res Treat 2016:4161738
van Halsema, Clare L; Chihota, Violet N; Gey van Pittius, Nicolaas C et al. (2015) Clinical Relevance of Nontuberculous Mycobacteria Isolated from Sputum in a Gold Mining Workforce in South Africa: An Observational, Clinical Study. Biomed Res Int 2015:959107
Subbarao, Sathyavani; Wilkinson, Katalin A; van Halsema, Clare L et al. (2015) Raised Venous Lactate and Markers of Intestinal Translocation Are Associated With Mortality Among In-Patients With HIV-Associated TB in Rural South Africa. J Acquir Immune Defic Syndr 70:406-13
Meyers, Tammy; Sawry, Shobna; Wong, Jessica Y et al. (2015) Virologic failure among children taking lopinavir/ritonavir-containing first-line antiretroviral therapy in South Africa. Pediatr Infect Dis J 34:175-9
Otwombe, Kennedy N; Petzold, Max; Martinson, Neil et al. (2014) A review of the study designs and statistical methods used in the determination of predictors of all-cause mortality in HIV-infected cohorts: 2002-2011. PLoS One 9:e87356
Steegen, Kim; Levin, Leon; Ketseoglou, Irene et al. (2014) High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen. PLoS One 9:e97067
Marshall, R C; Tlagadi, A; Bronze, M et al. (2014) Lower frequency of NPM1 and FLT3-ITD mutations in a South African adult de novo AML cohort. Int J Lab Hematol 36:656-64
Marais, Suzaan; Wilkinson, Katalin A; Lesosky, Maia et al. (2014) Neutrophil-associated central nervous system inflammation in tuberculous meningitis immune reconstitution inflammatory syndrome. Clin Infect Dis 59:1638-47

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