- OVERALL The Mutant Mouse Resource and Research Center (MMRRC) is the nation?s primary mutant mouse archive and distribution repository system, the primary goal of which is to facilitate research by identifying, acquiring, evaluating, characterizing, cryopreserving, and distributing mutant mouse strains to qualified biomedical investigators. The MMRRC was established by the NIH to ensure the preservation, dissemination, and development of valuable mutant mouse lines and data generated by research scientists. The MMRRC is a consortium of four Centers, each hosting an archive and distribution repository, and an Informatics Coordination and Service Center (ICSC) within a trans-national network regionally distributed across the United States. The Centers collectively serve the needs of the nation?s biomedical research community, ensuring access to and optimizing utilization of transgenic, knockout, and other genetically engineered mutant mice and related biomaterials, services, and new technologies. The Centers import, verify, maintain, and distribute mice, gene-targeted embryonic stem (ES) cells, and germplasm of genetically unique, scientifically valuable mice. Centers also provide services and procedures to assist investigators using genetically altered mice for research. Finally, Centers conduct resource-related research, often collaboratively, to further refine and develop mutant mouse lines and capitalize on the power of mouse genetics for biomedical research. By depositing their mutant mice in repositories at the Centers, NIH-funded investigators fulfill their obligation under the NIH Sharing Policy. In return, each of the Centers strives to preserve, protect, quality control, and provide these models for the benefit of research scientists and investigators across the nation and the globe. In doing so, the MMRRC ensures that valuable mutant mouse lines are available equitably across the biomedical research community, thereby accelerating the pace of research and discovery using genetically altered mice.

Public Health Relevance

Genetically-engineered mice are instrumental to better understand human development and disease and to develop and improve drugs and therapeutics. The Mutant Mouse Resource and Research Center at the University of Missouri provides a unique repository for importing, storing and distributing a vast number of genetically-engineered mice, germplasm, embryonic stem cells and related reagents. The center also performs critical broad-based research and services to ensure quality, reproducibility and translatability of mouse models with an emphasis on the role of complex gut microbiota in model phenotypes.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010918-22
Application #
10116512
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Mirochnitchenko, Oleg
Project Start
2000-05-01
Project End
2025-02-28
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
22
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211
Korte, Scott W; Franklin, Craig L; Dorfmeyer, Rebecca A et al. (2018) Effects of Fenbendazole-impregnated Feed and Topical Moxidectin during Quarantine on the Gut Microbiota of C57BL/6 Mice. J Am Assoc Lab Anim Sci 57:229-235
Bidot, Willie A; Ericsson, Aaron C; Franklin, Craig L (2018) Effects of water decontamination methods and bedding material on the gut microbiota. PLoS One 13:e0198305
Hart, Marcia L; Ericsson, Aaron C; Lloyd, K C Kent et al. (2018) Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies. Sci Rep 8:10107
Montonye, Dan R; Ericsson, Aaron C; Busi, Susheel B et al. (2018) Acclimation and Institutionalization of the Mouse Microbiota Following Transportation. Front Microbiol 9:1085
Riesenberg, Amy N; Conley, Kevin W; Le, Tien T et al. (2018) Separate and coincident expression of Hes1 and Hes5 in the developing mouse eye. Dev Dyn 247:212-221
Niwa, Takahiko; Yamakoshi, Yasuo; Yamazaki, Hajime et al. (2018) The dynamics of TGF-? in dental pulp, odontoblasts and dentin. Sci Rep 8:4450
Ericsson, Aaron C; Gagliardi, Jonalyn; Bouhan, Delia et al. (2018) The influence of caging, bedding, and diet on the composition of the microbiota in different regions of the mouse gut. Sci Rep 8:4065
Khairallah, Marie-Therese; Astroski, Jacob; Custer, Sarah K et al. (2017) SMN deficiency negatively impacts red pulp macrophages and spleen development in mouse models of spinal muscular atrophy. Hum Mol Genet 26:932-941
Franklin, Craig L; Ericsson, Aaron C (2017) Microbiota and reproducibility of rodent models. Lab Anim (NY) 46:114-122
Hart, Marcia L; Ericsson, Aaron C; Franklin, Craig L (2017) Differing Complex Microbiota Alter Disease Severity of the IL-10-/- Mouse Model of Inflammatory Bowel Disease. Front Microbiol 8:792

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