Project Start
2005-09-01
Project End
2006-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
5
Fiscal Year
2005
Total Cost
$2,937,964
Indirect Cost
Name
University of Florida
Department
Pediatrics
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Gruntman, Alisha M; Flotte, Terence R (2015) Progress with Recombinant Adeno-Associated Virus Vectors for Gene Therapy of Alpha-1 Antitrypsin Deficiency. Hum Gene Ther Methods 26:77-81
Conlon, Thomas J; Erger, Kirsten; Porvasnik, Stacy et al. (2013) Preclinical toxicology and biodistribution studies of recombinant adeno-associated virus 1 human acid ?-glucosidase. Hum Gene Ther Clin Dev 24:127-33
Brantly, Mark L; Chulay, Jeffrey D; Wang, Lili et al. (2009) Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy. Proc Natl Acad Sci U S A 106:16363-8
Flotte, Terence R; Goetzmann, Jason; Caridi, James et al. (2008) Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees. Hum Gene Ther 19:681-9
Flotte, Terence R; Conlon, Thomas J; Poirier, Amy et al. (2007) Preclinical characterization of a recombinant adeno-associated virus type 1-pseudotyped vector demonstrates dose-dependent injection site inflammation and dissemination of vector genomes to distant sites. Hum Gene Ther 18:245-56
Flotte, Terence R (2005) Adeno-associated virus-mediated gene transfer for lung diseases. Hum Gene Ther 16:643-8
Flotte, Terence R; Berns, Kenneth I (2005) Adeno-associated virus: a ubiquitous commensal of mammals. Hum Gene Ther 16:401-7
Flotte, Terence R (2005) Recent developments in recombinant AAV-mediated gene therapy for lung diseases. Curr Gene Ther 5:361-6
Flotte, T R (2004) Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors. Gene Ther 11:805-10
Chen, Sifeng; Agarwal, Anupam; Glushakova, Olena Y et al. (2003) Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors. J Am Soc Nephrol 14:947-58

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