Type I diabetes results from the body's failure to produce insulin, the hormone that """"""""unlocks"""""""" the cells of the body, allowing glucose to enter and fuel them. It is estimated that 20.8 Million Americans have diabetes; type I diabetes accounts for 5 to 10%of cases (approximately 1.56 Million type I diabetic patients). Keeping blood glucose levels under tight control represents the most effective way either to prevent the onset or to reduce the progression of the chronic complications of type I diabetes, such as blindness, kidney failure and cardiovascular diseases. Islet transplantation can achieve insulin independence, glucose control and freedom of hypoglycemic attacks in patients afflicted with Type I diabetes mellitus. However, the recovery of functional pancreatic islets from cadaveric donor pancreata is a complex procedure and needs to be optimized. Until an unlimited source of human pancreatic islet cell becomes available, the further development of endocrine replacement therapy for the treatment of diabetes will solely depend on the availability of high quality islet preparations, both for clinical application and laboratory-based research. Because of the complexity of the islet isolation procedure, it would be desirable to concentrate the know-how in a limited number of centers or consortiums to allow for optimal use of available resources.
The aim of this application is to extend the existing human islet core facility at the University of Illinois and the Chicago Islet Consortium into a federally funded Islet Cell Resource Center to isolate, purify, characterize and distribute human pancreatic islet cells for both transplantation into diabetic patients and use in laboratory studies to a larger community. The ICR at UIC with its partners in the Chicago Islet Consortium will be responsible for the procurement of whole pancreata, isolation and quality control of islet cell preparations, and distribution of islets for approved research or clinical protocols. The ICR at UIC is conducting research and development to improve isolation techniques, cellular viability and function, and shipping procedures, and is investigating methods for improved assessment of islet mass, composition, quality and viability. In addition, and most importantly for the progres of the field, the ICR at UIC will continue to provide large numbers of high-quality islet preparations for transplantation in diabetic patients.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
3U42RR023245-01S1
Application #
7501060
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Rosenblum, Daniel
Project Start
2006-09-30
Project End
2009-07-31
Budget Start
2006-09-30
Budget End
2007-07-31
Support Year
1
Fiscal Year
2008
Total Cost
$47,281
Indirect Cost
Name
University of Illinois at Chicago
Department
Surgery
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Vetri, Francesco; Qi, Meirigeng; Xu, Haoliang et al. (2017) Impairment of neurovascular coupling in Type 1 Diabetes Mellitus in rats is prevented by pancreatic islet transplantation and reversed by a semi-selective PKC inhibitor. Brain Res 1655:48-54
Marchese, Enza; Rodeghier, Caitlin; Monson, Rebecca S et al. (2015) Enumerating ?-Cells in Whole Human Islets: Sex Differences and Associations With Clinical Outcomes After Islet Transplantation. Diabetes Care 38:e176-7
Qi, Meirigeng; Kinzer, Katie; Danielson, Kirstie K et al. (2014) Five-year follow-up of patients with type 1 diabetes transplanted with allogeneic islets: the UIC experience. Acta Diabetol 51:833-43
Paushter, Daniel H; Qi, Meirigeng; Danielson, Kirstie K et al. (2013) Histidine-tryptophan-ketoglutarate and University of Wisconsin solution demonstrate equal effectiveness in the preservation of human pancreata intended for islet isolation: a large-scale, single-center experience. Cell Transplant 22:1113-21
Danielson, Kirstie K; Hatipoglu, Betul; Kinzer, Katie et al. (2013) Reduction in carotid intima-media thickness after pancreatic islet transplantation in patients with type 1 diabetes. Diabetes Care 36:450-6
Kaddis, John S; Hanson, Matthew S; Cravens, James et al. (2013) Standardized transportation of human islets: an islet cell resource center study of more than 2,000 shipments. Cell Transplant 22:1101-11
Rink, Jonathan S; Chen, Xiaojuan; Zhang, Xiaomin et al. (2012) Conditional and specific inhibition of NF-?B in mouse pancreatic ? cells prevents cytokine-induced deleterious effects and improves islet survival posttransplant. Surgery 151:330-9
Wang, Yong; Lee, Dongyoung; Zhang, Lisa et al. (2012) Systematic prevention of bubble formation and accumulation for long-term culture of pancreatic islet cells in microfluidic device. Biomed Microdevices 14:419-26
Morch, Yrr A; Qi, Meirigeng; Gundersen, Per Ole M et al. (2012) Binding and leakage of barium in alginate microbeads. J Biomed Mater Res A 100:2939-47
Qi, Meirigeng; Mørch, Yrr; Lacík, Igor et al. (2012) Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+ and Ba2+. Xenotransplantation 19:355-64

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