) In the face of improved US cancer survival, cancer mortality in American Indians is increasing. Cultural differences make addressing this disparity challenging. The paucity of American Indian health care providers, almost none oncologists, compounds the situation. American Indian patients, unable to effectively communicate with providers, become isolated from cancer diagnosis and treatment and are rarely recruited into clinical trials. While the need for American Indian oncologists is therefore urgent, few American Indians enter health care professions. While most universities have dismal recruitment and retention rates, Northern Arizona University (NAU) has a distinguished history of graduating Native American students. At NAU, however, there is no cancer research core to provide cancer education to American Indian students and communities. In this partnership, we will link research programs of the Arizona Cancer Center (AZCC) with American Indian student training programs and environmental research at NAU. While informal faculty interaction exists, there is currently no comprehensive plan to enhance cancer research at NAU or to coordinate American Indian student recruitment and retention at NAU and UofA/AZCC. The objectives of this proposal are to (1)initiate robust cancer research at NAU to enhance faculty career development and train students in cancer research fundamentals; (2) create stable, long-term cancer research, education, and outreach collaboration; and (3) improve institutional effectiveness in impacting the disparity in cancer in American Indians of the Southwest. Research programs will focus on the carcinogenic effects of chemicals associated with the mining industry on reservations. American Indian students have a vital interest in the data. Thus this vested interest greatly enhances our potential to recruit and retain these students and to provide future American Indian cancer researchers and oncologists. The program is guided by administrative, planning and developmental cores at each institution. Research activities include basic science, cancer education, and community outreach components. We propose 6 pilot projects, 4 full projects, and recruitment of 2 new faculty over the project lifetime.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA096320-05
Application #
7115367
Study Section
Special Emphasis Panel (ZCA1-SRRB-7 (J1))
Program Officer
Ogunbiyi, Peter
Project Start
2002-06-20
Project End
2009-11-30
Budget Start
2006-09-11
Budget End
2009-11-30
Support Year
5
Fiscal Year
2006
Total Cost
$983,931
Indirect Cost
Name
Northern Arizona University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
806345542
City
Flagstaff
State
AZ
Country
United States
Zip Code
86011
Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38
Huenneke, Laura F; Stearns, Diane M; Martinez, Jesse D et al. (2017) Key Strategies for Building Research Capacity of University Faculty Members. Innov High Educ 42:421-435
Ma, Wai Kit; Hendrix, Rachel; Stewart, Claire et al. (2013) FlgM proteins from different bacteria exhibit different structural characteristics. Biochim Biophys Acta 1834:808-16
Robinson, Marin S; Zhao, Min; Zack, Lindsay et al. (2011) Characterization of PM(2.5) collected during broadcast and slash-pile prescribed burns of predominately ponderosa pine forests in northern Arizona. Atmos Environ (1994) 45:2087-2094
George, Shannon A; Whittaker, Aaron M; Stearns, Diane M (2011) Photoactivated uranyl ion produces single strand breaks in plasmid DNA. Chem Res Toxicol 24:1830-2
Heintze, Ellie; Aguilera, Camille; Davis, Malia et al. (2011) Toxicity of depleted uranium complexes is independent of p53 activity. J Inorg Biochem 105:142-8
Sanderson, Priscilla R; Teufel-Shone, Nicolette I; Baldwin, Julie A et al. (2010) Breast cancer education for Navajo women: a pilot study evaluating a culturally relevant video. J Cancer Educ 25:217-23
Webber, Tawnya M; Allen, Andrew C; Ma, Wai Kit et al. (2009) Conformational detection of p53's oligomeric state by FlAsH Fluorescence. Biochem Biophys Res Commun 384:66-70
Webber, Tawnya; Gurung, Sarsati; Saul, Justin et al. (2009) The C-terminus of the P22 tailspike protein acts as an independent oligomerization domain for monomeric proteins. Biochem J 419:595-602
Raymond-Whish, Stefanie; Mayer, Loretta P; O'Neal, Tamara et al. (2007) Drinking water with uranium below the U.S. EPA water standard causes estrogen receptor-dependent responses in female mice. Environ Health Perspect 115:1711-6

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