The goal of this Team is the clinical application of the methods of Optical Pharmacokinetics (OP) and Elastic Scattering Spectroscopy (ESS) for the management of photodynamic therapy (PDT) in the treatment of cancer and other pathologies. OP will be used to monitor local tissue concentrations andbiodistribution of PDT agents, providing patient-specific information on dosage and optimal time foractivation. ESS will be used as an adjunct to follow the response of tissues to treatment by sensingchanges in the tissue optical properties. The short-term objectives are to detect and resolve any limitations for clinical implementation, to demonstrate that these are clinically """"""""friendly"""""""" modalities, and to generate the computational/numerical tools that will provide the measured results in real time during clinical treatment. The ideal implementation of PDT requires delivery of both the proper drug dosage and the proper light """"""""dosage"""""""", which in turn requires understanding of the optical properties of the tissue and knowledge of drug concentration in the tissue of interest. In vivo measurements would provide information on patient-patient variability in the uptake of the drug and, therefore, make possible individual dosimetry for PDT. In addition, the site-specific time history of the drug is especially important because the photoactivation should be done when the ratio of drug concentration in the tumor to surrounding tissue is at a maximum. The Primary Projects address both animal and clinical studies to answer a series of questions aimed at validating the capabilities and sensitivities of the spectroscopic methods and assessing the implications of those aspects of the methods that impact clinical utility and health-care significance. The Technical Support Core-provides-the-instrumentation-and the mathematical tools to all Projects and facilitates the data analysis. The Administrative Core provides the superstructure of the Team, especially to facilitate communication and information sharing, both within this Team and among all the Teams of the Network.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA104677-02
Application #
6807007
Study Section
Special Emphasis Panel (ZCA1-SRRB-D (O1))
Program Officer
Baker, Houston
Project Start
2003-09-30
Project End
2008-08-31
Budget Start
2004-09-17
Budget End
2005-08-31
Support Year
2
Fiscal Year
2004
Total Cost
$1,146,889
Indirect Cost
Name
Boston University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215
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Calabro, Katherine W; Bigio, Irving J (2014) Influence of the phase function in generalized diffuse reflectance models: review of current formalisms and novel observations. J Biomed Opt 19:75005
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Ergin, Aysegul; Wang, Mei; Zhang, Jane et al. (2012) Noninvasive in vivo optical assessment of blood brain barrier permeability and brain tissue drug deposition in rabbits. J Biomed Opt 17:057008
Bigio, Irving J (2012) Real-time pathology to guide breast surgery: seeing alone is not believing. Clin Cancer Res 18:6083-5
Joshi, Shailendra; Ergin, Aysegul; Wang, Mei et al. (2011) Inconsistent blood brain barrier disruption by intraarterial mannitol in rabbits: implications for chemotherapy. J Neurooncol 104:11-9
Rodriguez-Diaz, Eladio; Castanon, David A; Singh, Satish K et al. (2011) Spectral classifier design with ensemble classifiers and misclassification-rejection: application to elastic-scattering spectroscopy for detection of colonic neoplasia. J Biomed Opt 16:067009
Joshi, Shailendra; Reif, Roberto; Wang, Mei et al. (2011) Intra-arterial mitoxantrone delivery in rabbits: an optical pharmacokinetic study. Neurosurgery 69:706-12; discussion 712
Rodriguez-Diaz, Eladio; Bigio, Irving J; Singh, Satish K (2011) INTEGRATED OPTICAL TOOLS FOR MINIMALLY INVASIVE DIAGNOSIS AND TREATMENT AT GASTROINTESTINAL ENDOSCOPY. Robot Comput Integr Manuf 27:249-256
Keshtgar, M R S; Chicken, D W; Austwick, M R et al. (2010) Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer. Br J Surg 97:1232-9

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