Abstract

Core 5 will continue to be responsible for the dissemination of the MAGNet Center software platform, geWorkbench, and its associated tools and data. To achieve our goals, we will use outreach activities (conference presentations, training workshops, publications) and a significant and well established support infrastructure (project web site, user forums, expert support, collaborative development tools). These tools will help us proactively promote the Center's technologies and adoption by members of our dual target audience: biomedical researchers with varying degrees of computational skills and geWorkbench open-source component developers. Further, we will continue building on the success of our DREAM conference and challenges to critically assess the quality of Systems Biology tools and algorithms using objective experimental benchmarks, similar to what the CASP conference has achieved for the Structural Biology community.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54CA121852-06
Application #
8045769
Study Section
Special Emphasis Panel (ZRG1-BST-K (52))
Project Start
2010-09-21
Project End
2015-07-31
Budget Start
2010-09-21
Budget End
2011-07-31
Support Year
6
Fiscal Year
2010
Total Cost
$166,106
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Hui, Ken Y; Fernandez-Hernandez, Heriberto; Hu, Jianzhong et al. (2018) Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med 10:
Azad, Robert N; Zafiropoulos, Dana; Ober, Douglas et al. (2018) Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations. Nucleic Acids Res 46:2636-2647
Abe, Takayuki; Lee, Albert; Sitharam, Ramaswami et al. (2017) Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization. Immunity 46:621-634
Alvarez, Mariano J; Shen, Yao; Giorgi, Federico M et al. (2016) Functional characterization of somatic mutations in cancer using network-based inference of protein activity. Nat Genet 48:838-47
Sheng, Ren; Jung, Da-Jung; Silkov, Antonina et al. (2016) Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain. J Biol Chem 291:17639-50
Lachmann, Alexander; Giorgi, Federico M; Lopez, Gonzalo et al. (2016) ARACNe-AP: gene network reverse engineering through adaptive partitioning inference of mutual information. Bioinformatics 32:2233-5
Park, Mi-Jeong; Sheng, Ren; Silkov, Antonina et al. (2016) SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins. Mol Cell 62:7-20
Baskovich, Brett; Hiraki, Susan; Upadhyay, Kinnari et al. (2016) Expanded genetic screening panel for the Ashkenazi Jewish population. Genet Med 18:522-8
Bisikirska, Brygida; Bansal, Mukesh; Shen, Yao et al. (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76:664-74
Del Giudice, Ilaria; Marinelli, Marilisa; Wang, Jiguang et al. (2016) Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments. Br J Haematol 172:371-383

Showing the most recent 10 out of 258 publications