The 4DB Center will be directed by the PI, Peter Kuhn (physics), who will be assisted by senior co-investigator Kelly Bethel (oncology). Both are voting members of the Center Advisory Committee (CAC) and will be joined by John Griffin (hematology) and Paul Newton (mathematics/physics). Along with four external scientific advisors as non-voting members and an NCI representative, they will oversee all programmatic and organizational aspects of the Center, its integration with the PS-OC Network and its education and outreach mission. An internal physics oncology interface board will provide additional guidance and institutional support. A key aspect of the CAC's responsibilities will be the development of pilot and trans-network projects to further the 4DB Center research goals as well as to complement the research of the other PS-OC Network centers. The project manager, Enrique Abola, will be responsible for the day-to-day center operations and will report to Drs. Kuhn and Bethel, who are responsible for communication and interaction with the PS-OCs Steering Committee (PSC). The 4DB Center data sharing and communication will be integrated through an enterprise-class software system consisting of a database system, web portal and standalone software programs for data/sample tracking and data annotation/collaboration.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA143906-01
Application #
7789838
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Program Officer
Lee, Jerry S
Project Start
2009-09-30
Project End
2011-08-31
Budget Start
2009-09-30
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$2,004,025
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
West, Jeffrey; Newton, Paul K (2017) Chemotherapeutic Dose Scheduling Based on Tumor Growth Rates Provides a Case for Low-Dose Metronomic High-Entropy Therapies. Cancer Res 77:6717-6728
Kuhn, P; Keating, S M; Baxter, G T et al. (2017) Lessons Learned: Transfer of the High-Definition Circulating Tumor Cell Assay Platform to Development as a Commercialized Clinical Assay Platform. Clin Pharmacol Ther 102:777-785
Carlsson, Anders; Kuhn, Peter; Luttgen, Madelyn S et al. (2017) Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters. Clin Cancer Res 23:1722-1732
West, Jeffrey; Hasnain, Zaki; Mason, Jeremy et al. (2016) The prisoner's dilemma as a cancer model. Converg Sci Phys Oncol 2:
West, Jeffrey; Hasnain, Zaki; Macklin, Paul et al. (2016) AN EVOLUTIONARY MODEL OF TUMOR CELL KINETICS AND THE EMERGENCE OF MOLECULAR HETEROGENEITY DRIVING GOMPERTZIAN GROWTH. SIAM Rev Soc Ind Appl Math 58:716-736
Mitrugno, Annachiara; Tormoen, Garth W; Kuhn, Peter et al. (2016) The prothrombotic activity of cancer cells in the circulation. Blood Rev 30:11-9
Ruiz, Carmen; Li, Julia; Luttgen, Madelyn S et al. (2015) Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. Phys Biol 12:016008
Baker-Groberg, Sandra M; Phillips, Kevin G; Healy, Laura D et al. (2015) Critical behavior of subcellular density organization during neutrophil activation and migration. Cell Mol Bioeng 8:543-552
Phillips, Kevin G; Lee, Angela M; Tormoen, Garth W et al. (2015) The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation. Am J Physiol Cell Physiol 308:C229-36
King, Michael R; Phillips, Kevin G; Mitrugno, Annachiara et al. (2015) A physical sciences network characterization of circulating tumor cell aggregate transport. Am J Physiol Cell Physiol 308:C792-802

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