; Project 5: Stationary Breast Tomosynthesis Breast cancer is the second most common cancer type among women. Over 10% of women develop breast cancer during their lifetimes and 30% to 40% of these patients die from the disease, Early detection is viewed as the best hope to decrease mortality. Full-field digital mammography (FFDM) is the current gold standard for early detection but has it limitations. Digital breast tomosynthesis (DBT), a 3-D imaging technique. Is generally considered to be the next generation screening device with the potential for improved performance compared to FFDM. In the U.S., DBT scanners from 3 leading commercial vendors are in advanced stages of clinical trials. Recent clinical studies have shown that DBT, while having better detection capability for masses compared to FFDM, suffers from lower sensitivity for micro-calcifications (MC) which is critical for early cancer identification. The low MC detectability is attributed mainly to the low image resolution due to motion blurring of both the patient and the x-ray source during the relatively long scanning time. The goal of this project is to develop a novel stationary DBT (s-DBT) technology that has the potential to improve our capability for early detection of human breast tumors. The key enabling technology is the carbon nanotube (CNT) based multi-beam field emission x-ray (MBFEX) that was pioneered by our team. During the first CCNE program, we proposed the s-DBT concept and demonstrated the possibility of constructing a s-DBT scanner with significantly increased scanning speed and spatial resolution compared to the current DBT technology. Our hypothesis is that the high spatial resolution will improve the sensitivity for both masses and micro-calcifications. In addition, the fast scanning speed will reduce patient discomfort due to prolonged compression. For this project we will develop a clinical-test ready prototype s-DBT system and validate its performance through phantom measurements and reader studies. The research will be carried out in close collaboration with Hologic, a market leader in women's healthcare and one of the major developers of the DBT technology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA151652-04
Application #
8540383
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
2013-08-01
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$101,421
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Sun, Junjiang; Shao, Wenwei; Chen, Xiaojing et al. (2018) An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs. Mol Ther Methods Clin Dev 10:257-267
Liu, Lina; Wang, Yuhua; Miao, Lei et al. (2018) Combination Immunotherapy of MUC1 mRNA Nano-vaccine and CTLA-4 Blockade Effectively Inhibits Growth of Triple Negative Breast Cancer. Mol Ther 26:45-55
Starling, Brittney R; Kumar, Parag; Lucas, Andrew T et al. (2018) Mononuclear phagocyte system function and nanoparticle pharmacology in obese and normal weight ovarian and endometrial cancer patients. Cancer Chemother Pharmacol :
Chai, Zheng; Zhang, Xintao; Rigsbee, Kelly Michelle et al. (2018) Cryoprecipitate augments the global transduction of the adeno-associated virus serotype 9 after a systemic administration. J Control Release 286:415-424
Wang, Yuhua; Zhang, Lu; Xu, Zhenghong et al. (2018) mRNA Vaccine with Antigen-Specific Checkpoint Blockade Induces an Enhanced Immune Response against Established Melanoma. Mol Ther 26:420-434
Pei, Xiaolei; He, Ting; Hall, Nikita E et al. (2018) AAV8 virions hijack serum proteins to increase hepatocyte binding for transduction enhancement. Virology 518:95-102
Zhang, Xintao; He, Ting; Chai, Zheng et al. (2018) Blood-brain barrier shuttle peptides enhance AAV transduction in the brain after systemic administration. Biomaterials 176:71-83
Shi, Kai; Zhao, Yi; Miao, Lei et al. (2017) Dual Functional LipoMET Mediates Envelope-type Nanoparticles to Combinational Oncogene Silencing and Tumor Growth Inhibition. Mol Ther 25:1567-1579
Goodwin, Tyler J; Huang, Leaf (2017) Investigation of phosphorylated adjuvants co-encapsulated with a model cancer peptide antigen for the treatment of colorectal cancer and liver metastasis. Vaccine 35:2550-2557
Satterlee, Andrew B; Attayek, Peter; Midkiff, Bentley et al. (2017) A dosimetric model for the heterogeneous delivery of radioactive nanoparticles In vivo: a feasibility study. Radiat Oncol 12:54

Showing the most recent 10 out of 190 publications