Overview of the Resource. Given the inherent difficulties in obtaining large quantities of tissues from pancreatic cancer patients, we have devised and instituted a rapid autopsy program that is designed to harvest primary tumor and organs containing all metastatic deposits of tumor from individuals who die of pancreatic cancer. The process we have instituted allows us to harvest and rapidly freeze these tissues in a process that is completed within 5 hours of death. This process is unique and highly innovative as a tissue resource in that it allows us to capture the entire history disease progression for pancreatic cancer patients (from intact primary tumor and remaining precursor lesions through to distant metastases at all locations). For the purposes of this application, the resource will provide high quality frozen samples, slides for frozen sections, formalin fixed tissues, and associated body fluids (blood, serum, ascites) for all projects requiring tissues. The costs of acquiring these tissues in the rapid autopsy program are supported in part by our Cancer Center Support Grant and our Pancreatic Cancer SPORE Grant. The costs requested here are supplemental to that support and are required for the requisite sample processing and pathology support that is associated with supporting the projects proposed in this application.
| Barkeer, Srikanth; Chugh, Seema; Batra, Surinder K et al. (2018) Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis. Neoplasia 20:813-825 |
| Saxena, Sugandha; Hayashi, Yuri; Wu, Lingyun et al. (2018) Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis. Oncotarget 9:5931-5943 |
| Roy, Sohini; Bag, Arup K; Dutta, Samikshan et al. (2018) Macrophage-Derived Neuropilin-2 Exhibits Novel Tumor-Promoting Functions. Cancer Res 78:5600-5617 |
| Saxena, Sugandha; Purohit, Abhilasha; Varney, Michelle L et al. (2018) Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells. BMC Cancer 18:1283 |
| Kaur, Sukhwinder; Smith, Lynette M; Patel, Asish et al. (2017) A Combination of MUC5AC and CA19-9 Improves the Diagnosis of Pancreatic Cancer: A Multicenter Study. Am J Gastroenterol 112:172-183 |
| Gebregiworgis, Teklab; Purohit, Vinee; Shukla, Surendra K et al. (2017) Glucose Limitation Alters Glutamine Metabolism in MUC1-Overexpressing Pancreatic Cancer Cells. J Proteome Res 16:3536-3546 |
| Karmakar, Saswati; Seshacharyulu, Parthasarathy; Lakshmanan, Imayavaramban et al. (2017) hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells. Oncotarget 8:14806-14820 |
| Krishn, Shiv Ram; Kaur, Sukhwinder; Sheinin, Yuri M et al. (2017) Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance. Oncotarget 8:7025-7038 |
| Kumar, Sushil; Cruz, Eric; Joshi, Suhasini et al. (2017) Genetic variants of mucins: unexplored conundrum. Carcinogenesis 38:671-679 |
| Lakshmanan, Imayavaramban; Salfity, Shereen; Seshacharyulu, Parthasarathy et al. (2017) MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53. Clin Cancer Res 23:3906-3917 |
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