Cervical cancer screening has dramatically decreased cervical cancer mortality in the US, yet there is a strong need for optimization of cervical cancer screening due to many factors, including the availability of multiple screening tests;the availability of HPV immunization;the need to balance benefits and harms through selection of appropriate screening ages, intervals, and screening tests;the need to identify critical points of failure in the screening processes;and the massive economic costs of cervical cancer screening in the US. The existing Vermont PROSPR Research Center at the University of Vermont is a statewide registry of breast cancer screening with 20 years of experience in collecting integrated screening process data. In this revision application, the Vermont PROSPR Research Center (VPRC) proposes: (1) To collect high-quality, multilevel cervical cancer screening process data among women in the state of Vermont;and (2) To lead and participate in collaborative multicenter research projects within the PROSPR consortium. We will create a statewide registry of cervical cancer screening exams and biopsy results, which will include Pap smear, HPV tests, and cervical biopsies interpreted by 7 hospital laboratory facilities in the stat as well as such tests interpreted out of state for Vermont women attending the eleven Planned Parenthood clinics. The second tier of our approach will consist of more detailed screening process data ascertainment from the electronic health record systems of Fletcher Allen Health Care (affiliated with the University of Vermont), the Community Health Centers of Burlington, and Planned Parenthood of Northern New England. Together, this data will provide a rich source of high-quality cervical cancer screening data for a sizable and diverse population-based cohort that includes a wide range of the spectrum of health care settings experienced in the United States. We have assembled a multidisciplinary research team with extensive collaborative experience and expertise across the cervical cancer screening spectrum, including primary care, cervical pathology and HPV testing, diagnostic work-up and treatment, and comparative effectiveness research. We are well poised to rapidly contribute both important cervical cancer screening data to the PROSPR central data repository and valuable expertise towards the evaluation of the cervical cancer screening processes in collaborative projects.

Public Health Relevance

While cervical cancer screening has dramatically reduced cervical cancer mortality in the United States, there is an urgent need to improve its efficiency, effectiveness, and safety. We aim to collect high quality, comprehensive cervical cancer screening data and to contribute to and lead collaborative research projects within the PROSPR Consortium that will help to optimize cervical cancer screening.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1)
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Ogunbiyi, Peter
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University of Vermont & St Agric College
Schools of Medicine
United States
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Lee, Janie M; Abraham, Linn; Lam, Diana L et al. (2018) Cumulative Risk Distribution for Interval Invasive Second Breast Cancers After Negative Surveillance Mammography. J Clin Oncol 36:2070-2077
van den Broek, Jeroen J; van Ravesteyn, Nicolien T; Mandelblatt, Jeanne S et al. (2018) Comparing CISNET Breast Cancer Models Using the Maximum Clinical Incidence Reduction Methodology. Med Decis Making 38:112S-125S
Mandelblatt, Jeanne S; Near, Aimee M; Miglioretti, Diana L et al. (2018) Common Model Inputs Used in CISNET Collaborative Breast Cancer Modeling. Med Decis Making 38:9S-23S
McCarthy, Anne Marie; Barlow, William E; Conant, Emily F et al. (2018) Breast Cancer With a Poor Prognosis Diagnosed After Screening Mammography With Negative Results. JAMA Oncol 4:998-1001
Alagoz, Oguzhan; Ergun, Mehmet Ali; Cevik, Mucahit et al. (2018) The University of Wisconsin Breast Cancer Epidemiology Simulation Model: An Update. Med Decis Making 38:99S-111S
Onega, T; Zhu, W; Weiss, J E et al. (2018) Preoperative breast MRI and mortality in older women with breast cancer. Breast Cancer Res Treat 170:149-157
Hill, Deirdre A; Haas, Jennifer S; Wellman, Robert et al. (2018) Utilization of breast cancer screening with magnetic resonance imaging in community practice. J Gen Intern Med 33:275-283
Conant, Emily F; Sprague, Brian L; Kontos, Despina (2018) Beyond BI-RADS Density: A Call for Quantification in the Breast Imaging Clinic. Radiology 286:401-404
Hart, Vicki; Trentham-Dietz, Amy; Berkman, Amy et al. (2018) The association between post-diagnosis health behaviors and long-term quality of life in survivors of ductal carcinoma in situ: a population-based longitudinal cohort study. Qual Life Res 27:1237-1247
Schapira, Marilyn M; Barlow, William E; Conant, Emily F et al. (2018) Communication Practices of Mammography Facilities and Timely Follow-up of a Screening Mammogram with a BI-RADS 0 Assessment. Acad Radiol 25:1118-1127

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