Given the daunting scope of the challenge of drug resistance, a strong team science approach will be needed to bring a full array of translational research approaches to bear in order to deliver transformative breakthroughs that will impact patient care. In addition to managing fiscal and budgetary oversight, we will coordinate a regular process of collaborative meetings, to be coordinated by the PIs and Project Manager to ensure real-time collaborative data sharing and collective input on data interpretation and experimental design. We will establish shared resource ?cores? to provide investigators in this DRSC ready access to several key capabilities that will be crucial for the success of our research project portfolio. These shared resources will include (1) Patient-derived Organoid Generation, (2) Liquid Biopsy, (3) Genomics and (4) tissue acquisition, and allocation of resources will be overseen by the PIs and the Project Manager. The Administrative Core will also interface with key components of the collaborative leadership structure of the DRSCincluding: 1.) Project co-Leaders--Dr. Benes (Project 1), Dr. Heist (Project 2), Dr. Hacohen (Project 3) 2.) Disease Center Leadership?Dr. Shaw (lung), Dr. Flaherty (melanoma), Dr. Corcoran (GI) 3.) Shared Resource Core Leadership?Drs. Benes/Yilmaz (Patient-derived models), Drs. Hacohen/Getz (Genomics), Dr. Juric (Tissue acquisition), Liquid Biopsy (Drs. Adalsteinsson, Corcoran) 4.) DRSC Advisory Board?Drs. Haber, Chabner, Ryan, Hahn, Golub A major goal of the Administrative Core will be to foster collaboration within project teams, between project teams, and with other DRSC sites and the NCI.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
4U54CA224068-02
Application #
10000472
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Doyle, Laurence A
Project Start
Project End
2022-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
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