Our data science research is tied to three Driving Biomedical Problems that we will use to focus, test, and validate the data science methods. These problems represent major opportunities to improve human mobility and health. We propose the following specific aims: 1. Data Science Cores: Develop and disseminate data science tools to overcome several of the major challenges in exploiting big data in biomedical research. In particular, we will: a. Develop robust, flexible, and automated optimization tools for generating personalized biomechanical models and simulations from diverse experimental movement data. b. Create techniques to make predictions and classifications and identify insightful correlations from large sets of noisy, sparse, and complex data, whether discrete or time-varying. c. Develop tools to model the role of behavioral and social dynamics in human health based on information collected with smartphones and wearable activity monitors. d. Establish machine learning systems that integrate diverse data sources and modeling approaches to aid clinical decision-making and transparently communicate with clinicians

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54EB020405-02
Application #
8935803
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2015-06-01
Budget End
2016-05-31
Support Year
2
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
Halilaj, Eni; Rajagopal, Apoorva; Fiterau, Madalina et al. (2018) Machine learning in human movement biomechanics: Best practices, common pitfalls, and new opportunities. J Biomech 81:1-11
Lin, Zhiyuan; Althoff, Tim; Leskovec, Jure (2018) I'll Be Back: On the Multiple Lives of Users of a Mobile Activity Tracking Application. Proc Int World Wide Web Conf 2018:1501-1511
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Yong, Jennifer R; Silder, Amy; Montgomery, Kate L et al. (2018) Acute changes in foot strike pattern and cadence affect running parameters associated with tibial stress fractures. J Biomech 76:1-7
Halilaj, E; Le, Y; Hicks, J L et al. (2018) Modeling and predicting osteoarthritis progression: data from the osteoarthritis initiative. Osteoarthritis Cartilage 26:1643-1650
Agrawal, Monica; Zitnik, Marinka; Leskovec, Jure (2018) Large-scale analysis of disease pathways in the human interactome. Pac Symp Biocomput 23:111-122
Halilaj, E; Hastie, T J; Gold, G E et al. (2018) Physical activity is associated with changes in knee cartilage microstructure. Osteoarthritis Cartilage 26:770-774
Zieff, Susan G; Musselman, Elaine A; Sarmiento, Olga L et al. (2018) Talking the Walk: Perceptions of Neighborhood Characteristics from Users of Open Streets Programs in Latin America and the USA. J Urban Health 95:899-912
Rajagopal, Apoorva; Kidzi?ski, ?ukasz; McGlaughlin, Alec S et al. (2018) Estimating the effect size of surgery to improve walking in children with cerebral palsy from retrospective observational clinical data. Sci Rep 8:16344
Smuck, Matthew; Muaremi, Amir; Zheng, Patricia et al. (2018) Objective measurement of function following lumbar spinal stenosis decompression reveals improved functional capacity with stagnant real-life physical activity. Spine J 18:15-21

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