? Coordination Core. The proposed multidisciplinary Eye and Pancreas Tissue Mapping Center (TMC) for the Human BioMolecular Atlas Program (HuBMAP) requires diverse proficiencies including (1) the biological expertise and infrastructure required for acquisition of normal human tissue, (2) the analytical skills to produce highly multiplexed multimodal molecular imaging data, (3) computational expertise in integrating and mining complex data, and (4) a track record in collaboration between the TMC components and other HuBMAP consortium members. The Coordination Core (CC) will be a key center of administration for the proposed Vanderbilt University Eye and Pancreas Tissue Mapping Center (TMC).
The specific aims of the CC directly reflect its role to prioritize achievement of program milestones through effective leadership, sharing of data and samples, and communication with HuBMAP leadership as well as interaction among Consortium groups to provide a foundation of success for the Vanderbilt Eye and Pancreas TMC. Leadership for the proposed TMC include distinguished experts in their fields: Dr. Jeffrey Spraggins (MPI, BIOMIC Director, DAC Team Leader), Dr. Richard Caprioli (MPI, CC Team Leader), Dr. Alvin Powers (MPI, Pancreas OSP Team Leader), and Dr. Kevin Schey (MPI, Eye OSP co-Team Leader). These four have worked extensively together in rigorous and large-scale research programs, for which they have managed research activities, collaborations, and data coordination. To contribute productively to the HuBMAP consortium, the proposed Vanderbilt Eye and Pancreas TMC will share and accept protocols, samples, and data to promote and unify 3-D molecular atlas construction across the Consortium. The Vanderbilt team will follow and participate in the development of policies and procedures established by the Consortium, including those for data/specimen sharing and publications. The overall mission of the CC and for the proposed TMC is to successfully contribute to HuBMAP to establish 3-D molecular human tissue atlases that advance biomedical research.
