The Core is comprised of two components, Information Dissemination and InformationCoordination. The goal of the former is to disseminate information on technology, scientific findings andmethodologies as rapidly, yet responsibly, as possible. The goal of the latter is to provide hardware andsoftware infrastructure to manage, analyze, and distribute the sequence, expression, and structuralinformation, and information on Cell Migration activities, produced by the Cell Migration Consortium. TheConsortium's web site (www.cellmigration.org) is the major forum for information transfer. It has existed inthree editions. The initial web site announced the Consortium and outlined its organization, objectives,approaches, and activities. It also contained material of interest to the general migration community includingmeeting announcements, an introduction to Cell Migration for the general public, and initial Consortiumaccomplishments. The second edition was launched as the Consortium began to produce significant data,technologies, and other products. The activities section was expanded greatly to include detailed descriptionsof the Consortium activities and approaches for each initiative, descriptions on data release and collaborationpolicies, lists of completed, ongoing and planned activities, contact personnel, and the products of theinitiatives. The latter takes several forms depending on the initiative. For some, it could be a list of publications,software, or protocols. For others, e.g., the proteomics and discovery initiatives, it includes data sets. Finally,there are lists of pertinent, non Consortium generated resources, e.g., an inclusive list of biosensors orphosphorylation specific antibodies for the Biosensor Initiative. All of these data were coordinated and linked tothe Cell Migration Knowledgebase (CMKB, see below). The most recent edition is a result of collaboration withthe Nature Publishing Group (NPG), the goal being to bring our products to the attention of the broadestpossible audience, on the one hand, and to provide a resource for the field as a whole, by presenting not onlyConsortium generated information, but information about cell migration that goes beyond the Consortium.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54GM064346-06
Application #
7313369
Study Section
Special Emphasis Panel (ZGM1-CBB-2 (GL))
Project Start
2006-08-10
Project End
2011-07-31
Budget Start
2006-08-10
Budget End
2007-07-31
Support Year
6
Fiscal Year
2006
Total Cost
$83,333
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
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Kubow, Kristopher E; Shuklis, Victoria D; Sales, Dominic J et al. (2017) Contact guidance persists under myosin inhibition due to the local alignment of adhesions and individual protrusions. Sci Rep 7:14380
Gallegos, Lisa Leon; Ng, Mei Rosa; Sowa, Mathew E et al. (2016) A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for ?-catenin. Sci Rep 6:27114
Al-Dimassi, Saleh; Salloum, Gilbert; Saykali, Bechara et al. (2016) Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion. Int J Oncol 48:1913-20
Juanes-Garcia, Alba; Chapman, Jessica R; Aguilar-Cuenca, Rocio et al. (2015) A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity. J Cell Biol 209:23-32
Gao, Runchi; Zhao, Siwei; Jiang, Xupin et al. (2015) A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Sci Signal 8:ra50
Dai, Aguang; Ye, Feng; Taylor, Dianne W et al. (2015) The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand. J Biol Chem 290:27168-75
Khalil, Bassem D; Hanna, Samer; Saykali, Bechara A et al. (2014) The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility. Exp Cell Res 321:109-22
Ng, Mei Rosa; Besser, Achim; Brugge, Joan S et al. (2014) Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters. Elife 3:e03282
Moissoglu, Konstadinos; Kiessling, Volker; Wan, Chen et al. (2014) Regulation of Rac1 translocation and activation by membrane domains and their boundaries. J Cell Sci 127:2565-76

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