Abstract

Description): The objective of the Morphology Core will be to provide access to a variety of electron and light microscopic (EM and LM, respectively) services and equipment. Specialized cytochemical protocols worked our for reproductive biology tissues will be applied to support key center projects. In addition, there will be routine transmission and scanning electron microscopy and light microscopy, including cryosectioning, brightfield, phase contrast, DIC and immunofluorescence. The Core will also assist Center investigators in the design of experimental protocols that involve cytochemistry or morphology. The Core will also prepare images for publication. Finally, the Core aims include some developmental work, making the new methods available to Center investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD037321-04
Application #
6588502
Study Section
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
$174,159
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Palmer, Stephen S; Altan, Melis; Denis, Deborah et al. (2016) Bentamapimod (JNK Inhibitor AS602801) Induces Regression of Endometriotic Lesions in Animal Models. Reprod Sci 23:11-23
Herington, Jennifer L; Bruner-Tran, Kaylon L; Lucas, John A et al. (2011) Immune interactions in endometriosis. Expert Rev Clin Immunol 7:611-26
Taylor, Robert N; Yu, Jie; Torres, Paulo B et al. (2009) Mechanistic and therapeutic implications of angiogenesis in endometriosis. Reprod Sci 16:140-6
Weiss, Gerson; Goldsmith, Laura T; Taylor, Robert N et al. (2009) Inflammation in reproductive disorders. Reprod Sci 16:216-29
Nayyar, Tultul; Bruner-Tran, Kaylon L; Piestrzeniewicz-Ulanska, Dagmara et al. (2007) Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis. Reprod Toxicol 23:326-36
Tee, Meng Kian; Vigne, Jean-Louis; Taylor, Robert N (2006) All-trans retinoic acid inhibits vascular endothelial growth factor expression in a cell model of neutrophil activation. Endocrinology 147:1264-70
Melner, Michael H; Haas, Arthur L; Klein, Jennifer M et al. (2006) Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expression. Biol Reprod 75:395-406
Bruner-Tran, Kaylon L; Zhang, Zhiming; Eisenberg, Esther et al. (2006) Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J Clin Endocrinol Metab 91:1554-60
Igarashi, Toshio M; Bruner-Tran, Kaylon L; Yeaman, Grant R et al. (2005) Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil Steril 84:67-74
Osteen, Kevin G; Bruner-Tran, Kaylon L; Eisenberg, Esther (2005) Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis. Fertil Steril 83:529-37

Showing the most recent 10 out of 49 publications